摘要
目的比较白球比(A/G)、门脉右支前间隙对肝脏纤维化的诊断价值。方法选取昆明医科大学第一附属医院2010年1月—2016年2月收治的肝纤维化患者98例,肝纤维化分期为S0期25例,S1期25例,S2期15例,S3期15例,S4期18例。采用病理检查及图像分析、血生化检查等,比较肝纤维化各分期A/G、门脉右支前间隙,并分析其与肝纤维化病理分期相关性,建立ROC曲线,分析A/G、门脉右支前间隙对肝纤维化S3、S4期的灵敏度、特异度。结果肝纤维化S1~S4期患者A/G值低于S0期,门脉右支前间隙高于S0期(P<0.05);肝纤维化S4期患者A/G值低于S0期(P<0.05);肝纤维化S3、S4期患者门脉右支前间隙高于S0期(P<0.01)。A/G值、门脉右支前间隙与肝纤维化病理分期经Spearman相关性分析结果显示,肝纤维化各期与A/G值呈负相关(r=-0.275,P<0.05),与门脉右支前间隙呈正相关(r=0.537,P<0.001)。门脉右支前间隙对肝纤维化S3、S4期AUC高于A/G值,且门脉右支前间隙对肝纤维化S3、S4期诊断灵敏度、特异度较A/G高。结论门脉右支前间隙对肝纤维化分期≥S3期患者具有一定的诊断价值,而A/G值仅在肝纤维化分期≥S4期有明显改变,因此门脉右支前间隙对肝纤维化的诊断价值较A/G值高。
Objective To compare the A/G ratio and anterior width of right branch of protal vein in the diagnosis of hepatic fibrosis. Methods A total of 96 cases of hepatic fibrosis patients were selected from January 2010 to February 2016 in the First Affiliated Hospital of Kunming Medical University,hepatic fibrosis degree were S0（ n = 25）,S1（ n = 25）,S2（ n =15）,S3（ n = 15）,S4（ n = 18）. All patients were given pathological examination and image analysis and blood biochemical tests,the A/G ratio and anterior width of right branch of protal vein were compared among different hepatic fibrosis degree,and the correlation between A/G ratio and anterior width of right branch of protal vein and hepatic fibrosis degree were analysed,Set up ROC to analyse sensitivity and specificity of A/G ratio and anterior width of right branch of protal vein to hepatic fibrosis S3,S4. Results The A/G ratio of hepatic fibrosis S3-S4 were lower than S0,anterior width of right branch of protal vein were higher than S0（ P 〈 0. 05）; the A/G ratio of hepatic fibrosis S4 was lower than S0（ P 〈 0. 05）; anterior width of right branch of protal vein of hepatic fibrosis S3, S4 were higher than S0（ P 〈 0. 05）. Spearman rank correlation analysis showed that negative correlation between A/G ratio and hepatic fibrosis stage（ r =-0. 275,P 〈 0. 05）,positive correlation between the width of anterior space of right portal vein enlarged with hepatic fibrosis stage（ r = 0. 537,P 〈 0. 001）. The AUC of anterior width of right branch of protal vein in the diagnosis of hepatic fibrosis was higher than A/G ratio, and the sensitivity and specificity f anterior width of right branch of protal vein in the diagnosis of hepatic fibrosis were higher than A/G ratio.Conclusion The anterior width of right branch of portal has great value in diagnosis of S3 and S4 fibrosis,A/G ratio has some value in the diagnosis of S4 fibrosis,so the anterior width of right branch of portal in the diagnosis of liver fibrosis is better than that o
出处
《中国全科医学》
CAS
北大核心
2017年第A02期9-12,共4页
Chinese General Practice
