摘要
目的探讨重症急性胰腺炎患者早期应用微创置管引流的治疗效果。方法选取2012年6月—2015年12月西南医科大学附属医院消化内科收治的90例重症急性胰腺炎患者为研究对象,随机分为研究组和对照组,各45例。对照组进行常规治疗,研究组进行微创置管引流治疗。观察并比较两组患者各炎性因子的变化、全身炎症反应综合征(SIRS)持续时间、肠道功能恢复时间以及多器官功能障碍综合征(MODS)的发生率。结果治疗后3 d、7d两组患者的TNF-α、CPR、IL-6低于治疗前,差异有统计学意义(P<0.05);治疗后7 d两组患者的IL-8低于治疗前,差异有统计学意义(P<0.05);治疗后3 d、7 d研究组的TNF-α、CPR、IL-6低于对照组,差异有统计学意义(P<0.05);治疗后7 d,研究组IL-8低于对照组,差异有统计学意义(P<0.05);研究组患者的SIRS持续时间、肠道功能恢复时间均短于对照组,差异有统计学意义(P<0.05);研究组患者MODS发生率低于对照组,差异有统计学意义(P<0.05)。结论重症急性胰腺炎患者早期应用微创置管引流能够降低炎性因子的水平,缓解炎性症状,并能缩短SIRS持续时间和肠道功能恢复时间,降低MODS发生率,临床疗效优于穿刺置管引流,值得推广应用。
Objective To investigate the effect of early minimally invasive catheter drainage in patients with severe acute pancreatitis. Methods A total of 90 patients with severe acute pancreatitis were enrolled in the Department of Gastroenterology of Affiliated Hospital of Southwest Medical University from June 2012 to December 2015,which were randomly divided into study group and control group,45 cases for each group. The control group underwent routine treatment,the study group underwent minimally invasive catheter drainage treatment. The changes in inflammatory factors,the duration of systemic inflammatory response syndrome( SIRS),the recovery of intestinal function,and the incidence of multiple organ dysfunction syndrome( MODS) were compared between the two groups. Results After the treatment of 3 d and 7 d,two groups of patients with factor-α( TNF-α),C-reactive protein( CPR),interleukin-6( IL-6) alpha lower than that before treatment,the difference was statistically significant( P < 0. 05); after treatment of 7 days,two groups of patients with IL-8 was lower than that before treatment,the difference was statistically significant( P < 0. 05); the levels of TNF-α,CRP and IL-6 in the study group were lower than those in the control group at 3 d and 7 d after treatment( P < 0. 05). At 7 days after treatment,IL-8levels in the study group decreased and were lower than those in the control group( P < 0. 05),the differences were statistically significant. The duration of SIRS and the recovery time of intestinal function in the study group were shorter than those in the control group( P < 0. 05). The incidence of MODS in the study group was lower than that in the control group( P < 0. 05),the differences were statistically significant. Conclusion Early application of minimally invasive catheter drainage in patients with severe acute pancreatitis can reduce the level of inflammatory factors,relieve inflammatory symptoms,shorten the duration of SIRS and intestinal function recovery time,reduce the incidence of MODS, clinica
出处
《中国全科医学》
CAS
北大核心
2017年第A01期84-86,共3页
Chinese General Practice
关键词
胰腺炎
急性坏死性
引流术
全身炎症反应综合征
多器官功能衰竭
Pancreatitis
acute necrotizing
Drainage
Systemic inflammatory response syndrome
Multiple organ failure
