摘要
目的 探讨2型糖尿病患者并发周围血管病变与血清25-羟基维生素D3水平的相关性。方法 选择2014年10月至2016年10月在西安市中心医院内分泌科住院的2型糖尿病患者186例作为糖尿病组，并分为单纯2型糖尿病组（单纯组，100例）和2型糖尿病并发周围血管病变组（并发组，86例）。选择同期本院体检健康受试者80例作为正常组。依据血清25-羟基维生素D3水平的不同，将186例患者分为A组（4.0～12.0 μg/L）、B组（12.1～18.0 μg/L）和C组（18.1～24.0 μg/L），各62例。比较2型糖尿病患者和健康受试者临床资料、单纯组和并发组临床资料，采用多因素Logistic回归分析法分析2型糖尿病患者并发周围血管病变的影响因素，采用Pearson相关性分析法分析不同血清25-羟基维生素D3水平与2型糖尿病患者并发周围血管病变发生率的关系。结果 糖尿病组年龄、腰臀比、收缩压、舒张压、总胆固醇、三酰甘油、低密度脂蛋白胆固醇（LDL-C）、糖化血红蛋白（HbA1c）水平和吸烟史比例高于，而高密度脂蛋白胆固醇（HDL-C）、25-羟基维生素D3水平低于正常组，差异均有统计学意义（均P＜0.05）。糖尿病组男性、饮酒史比例和体重指数水平与正常组比较，差异均无统计学意义（均P＞0.05）。并发组年龄、体重指数、收缩压、舒张压、总胆固醇、LDL-C、HbA1c水平和吸烟史比例高于、而病程和25-羟基维生素D3水平短于（低于）单纯组，差异均有统计学意义（均P＜0.05）。并发组男性、饮酒史比例和腰臀比、三酰甘油、HDL-C水平与单纯组比较，差异均无统计学意义（均P＞0.05）。多因素Logistic回归分析法提示，2型糖尿病患者并发周围血管病变的危险因素有年龄、病程、吸烟史、收缩压、LDL-C和HbA1c；保护因素有25-羟基维生素D3（P＜0.05）。Pearson相关性分析法显示，血清25-羟基维生素D3水平
Objective To analyze the relation between peripheral vascular disease and serum 25-hydroxyvitamin D3[25-（OH）D3] in patients with type 2 diabetes mellitus（T2DM）. Methods One hundred and eighty-six patients with T2DM who were hospitalized in Xi′an Central Hospital from October 2014 to October 2016 were enrolled as T2DM group, they were divided into peripheral vascular disease group（86 cases） and non-complication group（100 cases）; 80 healthy people were enrolled as normal control group. According to serum level of 25-（OH）D3, 186 diabetic patients were divided into group A（4.0-12.0 μg/L）, group B（12.1-18.0 μg/L） and group C（18.1-24.0 μg/L）, with 62 cases in each group. Influence factors of peripheral vascular disease were analyzed by multivariate logistic regression. The relation between 25-（OH）D3 and peripheral vascular disease was analyzed by Pearson correlation analysis. Results Age, waist-to-hip ratio, systolic blood pressure, diastolic blood pressure, total cholesterol, triacylglycerol, low-density lipoprotein cholesterol（LDL-C）, glycosylated hemoglobin（HbA1c） level and smoking ratio in T2DM group were significantly higher and high-density lipoprotein cholesterol（HDL-C）, 25-（OH）D3 level were significantly shorter （lower） than those in normal control group（P〈0.05）. Male ratio, drinking ratio and body mass index had no significant differences between T2DM group and normal control group（P〉0.05）. Age, body mass index, systolic blood pressure, diastolic blood pressure, total cholesterol, LDL-C, HbA1c level and smoking ratio in peripheral vascular disease group were significantly higher and course of disease, 25-（OH）D3 level were significantly lower than those in non-complication group（P〈0.05）. Male ratio, drinking ratio, waist-to-hip ratio, triacylglycerol and HDL-C level had no significant differences between peripheral vascular disease group and non-complication group（P〉0.05）. Logistic regression analysis showed that age, co
出处
《中国医药》
2017年第11期1668-1672,共5页
China Medicine
基金
陕西省科学技术研究发展计划（2014K11-03-04-03）
