摘要
569例受试者（糖尿病高危人群）按稳态模型评估的β细胞功能指数（HOMA—IS）中位数，分为IS1组（HOMA-IS〉104．83）和IS2组（HOMA—IS≤104．83）。IS2组的血清25-（OH）D3、空腹胰岛素、体重指数、腰围和总胆固醇明显下降，空腹血糖和服糖后2h血糖明显上升。相关分析显示，HOMA—IS与体重指数、腰围、总胆固醇、血清25-（OH）D3均呈正相关关系（均P〈0．05），HOMA—IS与服糖后2hm糖呈负相关关系（P〈0．05）。提示在乌鲁木齐市水磨沟区糖尿病高危人群中，血清维生素D水平降低可能与胰岛β细胞功能损伤相关。
Five-hundred and sixty-nine subjects with high risk to diabetic mellitus were assigned into two groups according to the median of homeostasis model assessment for insulin sensitivity （ HOMA-IS ） ： IS1 group （ HOMA-IS〉 104.83 ） and IS2 group （ HOMA-IS ≤ 104.83 ）. Serum 25-（OH） D3 , fasting insulin, body mass index （BMI）, waist circumference （WC）, and total cholesterol （TC） were decreased, but fasting and postprandial blood glucose were increased in IS2 group. Positive correlations of HOMA-IS with serum 25-（OH） D3 , BMI, WC, and TC, while negative correlation with 2hPG were found （all P〈0.05）. It suggested that low level of serum vitamin D may be related to the isletβ-cell function in the people with high risk of diabetic mellitus in Shuimogou District of Urumqi.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2009年第6期626-628,共3页
Chinese Journal of Endocrinology and Metabolism
基金
新疆自然科学基金资助项目（200821111）
新疆医科大学创新基金资助项目
