摘要
目的 观察胰岛素泵强化治疗对新诊断2型糖尿病患者糖脂代谢、胰岛功能、炎性因子及氧化应激状态的影响。方法 选取2016年1月至2017年4月于天津医科大学第二医院新诊断2型糖尿病的患者共100例。完全随机分为观察组和对照组，每组50例。观察组采用胰岛素泵皮下持续输注胰岛素治疗，对照组采用胰岛素多次皮下注射治疗，均治疗2周。比较2组治疗前后血糖、血脂、胰岛功能、炎性因子及氧化应激等相关指标。结果 治疗前2组各项指标差异均无统计学意义（均P〉0.05）。治疗后2组空腹血糖、餐后2 h血糖、糖化血红蛋白差异无统计学意义（P〉0.05）。与治疗前比较，2组患者治疗后总胆固醇、三酰甘油、低密度脂蛋白胆固醇、稳态模型胰岛素抵抗指数、高敏C反应蛋白、白细胞介素6、肿瘤坏死因子α及丙二醛均明显下降，高密度脂蛋白胆固醇、空腹胰岛素、空腹C肽、稳态模型胰岛素分泌指数、谷胱甘肽过氧化物酶及超氧化物歧化酶均明显升高，且观察组这些指标的改善幅度较对照组更为显著，差异均有统计学意义［治疗后观察组与对照组比较：（4.3±1.0）mmol/L比（4.7±1.0）mmol/L、（1.6±0.7）mmol/L比（1.8±0.8）mmol/L、（2.5±0.7）mmol/L比（2.6±0.7）mmol/L、（3.3±0.9）比（4.2±1.0）、（1.3±1.0）mg/L比（2.0±1.2）mg/L、（7.3±1.7）ng/L比（8.9±1.6）ng/L、（0.86±0.20）ng/L比（1.15±0.27）ng/L、（2.3±0.7）μmol/L比（3.2±0.8）μmol/L、（2.0±1.0）mmol/L比（2.0±1.0）mmol/L、（23.7±1.3）mU/L比（17.8±2.0）mU/L、（1.89±0.38）μg/L比（1.42±0.29）μg/L、（99±21）比（82±18）、（186±20）U/L比（162±28）U/L、（37±10）U/L比（33±9）U/L］（均P〈0.05）。结论 对于新诊断2型糖尿病患者，使用胰岛素泵强化治疗能够有效控制血糖，调节脂代谢，减轻胰岛素抵抗，改善胰岛功能，降低炎性因子
Objective To analyze the effect of insulin pump intensive treatment on glycolipid metabolism, islet function, inflammatory factors and oxidative stress in newly diagnosed type 2 diabetic patients. Methods One hundred patients newly diagnosed of type 2 diabetes from January 2016 to April 2017 in the Second Hospital of Tianjin Medical University were randomly divided into observation group and control group with 50 cases in each group. The observation group had continuous subcutaneous insulin infusion by insulin pump; the control group had multiple subcutaneous injections of insulin. After 2 weeks of treatment, blood glucose, blood lipid, islet function, inflammatory factors and oxidative stress indexes were analyzed. Results There were no differences of laboratory indexes between groups before treatment（P〉0.05）. Fasting blood glucose, postprandial 2 h blood glucose and glycosylated hemoglobin had no differences between groups after treatment（P〉0.05）. After treatment, total cholesterol, triacylglycerol, low-density lipoprotein cholesterol, insulin resistant index, high-sensitive C-reactive protein, interleukin-6, tumor necrosis factor-α and malondialdehyde significantly decreased; high-density lipoprotein cholesterol, fasting insulin, fasting C-peptide, insulin secretion index, glutathione peroxidase and superoxide dismutase significantly increased; there were significant differences of these indexes between observation group and control group[（4.3±1.0）mmol/L vs （4.7±1.0）mmol/L, （1.6±0.7）mmol/L vs （1.8±0.8）mmol/L, （2.5±0.7）mmol/L vs （2.6±0.7）mmol/L, （3.3±0.9） vs （4.2±1.0）, （1.3±1.0）mg/L vs （2.0±1.2）mg/L, （7.3±1.7）ng/L vs （8.9±1.6）ng/L, （0.86±0.20）ng/L vs （1.15±0.27）ng/L, （2.3±0.7）μmol/L vs （3.2±0.8）μmol/L, （2.0±1.0）mmol/L vs （2.0±1.0）mmol/L, （23.7±1.3）mU/L vs （17.8±2.0）mU/L, （1.89±0.38）μg/L vs （1.42±0.29）μg/L, （99±21） vs （82±18）, （186±20）U/L vs （162±28）U/L, （37±10）U
出处
《中国医药》
2017年第11期1660-1664,共5页
China Medicine
关键词
糖尿病
2型
胰岛素泵
胰岛功能
炎性因子
氧化应激
Diabetes mellitus, type 2
Insulin pump
Islet function
Inflammation factors
Oxidative stress
