摘要
目的:观察益肾健脾化湿颗粒治疗脾肾气虚型代谢综合征微量白蛋白尿症的临床疗效及对尿微量白蛋白的影响。方法:将80例脾肾气虚型代谢综合征微量白蛋白尿患者随机分为2组各40例。对照组予西医常规治疗,治疗组在对照组基础上加用益肾健脾化湿颗粒治疗。2组疗程均为12周。观察比较2组尿微量白蛋白达标率及治疗前后体质量指数、血压、血脂(TC、TG、LDL-C、HDL-C)、血糖(FBG、Hb A1c)的变化。结果:治疗组尿微量白蛋白达标率为45.0%,明显高于对照组的27.5%,差异有统计学意义(P<0.05);治疗组治疗后体质量指数、血压、血脂、血糖水平均低于治疗前,并优于对照组治疗后,差异均有统计学意义(P<0.05)。结论:益肾健脾化湿颗粒联合西药治疗能改善脾肾气虚型代谢综合征微量白蛋白尿患者的各项指标,并可显著减少尿微量白蛋白。
Objective ： To investigate the clinical effect of kidney - nourishing, spleen - st engthening, and dampness - removing granules in the treatment of metabolic syndromecomplicated by microalbuminuria with the syndrome of spleen - kidney qi deficiency and its effect on urinary microalbmnin. Methods：A total of 80 patients with metabolic syndromecomplicated by microalbuminuria with the syndrome of spleen -kidney qi deficiency were randomly divided into control group and tr ~atmentgroup,with 40 patients in each group. The patients in the control group were given conventional Western medicine treatment, and those in the treatment group were given kidney- nourishing, spleen- strengthening, and dampness -removing granules in addition to the conventional Western medicine treatment. The course of treatment was 12 weeks for both groups. The two groups were compared in terms of control rate of urinary microalbumin and changes in body mass index（BMI） ,blood pressure, blood lipids（ total cholesterol ,triglyceride ,low -density lipoprotein cholesterol, and high- density lipoprotein cholesterol）, and blood glucose（fasting blood glucose and hemoglobin Alc）after treatment. Results ：The treatment group had a significantly higher control rate of urinary, microalbumin than the control group （45.0% vs 27. 5%, P 〈 0. 05 ）. The treatment group showed significant reductions in BMI, blood pressure, blood lipids, and blood glucose after treatment （P 〈 0. 05 ） and had significantly better results than the control group （ P 〈 0. 05 ）. Conclusion ： In patients with metabolic syndromecomplicated by microalbuminuria with the syndrome of spleen - kidney qi deficiency, kidney - nourishing, spleen - strength- ening, and dampness -removing granules can improve various indices and significantly reduce urinary microalbumin.
作者
冯占荣
马俊杰
张以来
魏善斋
FENG Zhan - rong;MA Jun - jie;ZHANG Yi - lai;WEI Shan- zhai(Shuyang Hospital of Traditional Chinese Medicine, Shuyang 223600, Jiangsu, China;Nanjing University of Chinese Medicine, Nanjing 210046 ,Jiangsu, China)
出处
《湖南中医杂志》
2017年第10期17-19,共3页
Hunan Journal of Traditional Chinese Medicine
基金
江苏省宿迁市指导性课题(编号:z201408)
关键词
代谢综合征
微量白蛋白尿
脾肾气虚证
中西医结合疗法
益肾健脾化湿颗粒
metabolic syndrome
microalbuminuria
syndrome of spleen - kidney qi deficiency
kidney - nourishing, spleen - strengthening, and dampness - removing granule
