摘要
目的探讨来氟米特联合糖皮质激素治疗进展性Ig A肾病的效果及对VCAM-1水平的影响。方法选取2015年3月~2017年1月在我院进行治疗的108例进展性Ig A肾病患者作为研究对象,根据就诊时间的不同分为治疗组与对照组,各54例。治疗组采用来氟米特联合糖皮质激素进行治疗,对照组采取强的松龙进行治疗,治疗结束后记录两组患者治疗效果、血清等检测指标、不良反应情况。结果治疗组治疗后的总有效率为92.59%,高于对照组的75.98%(P<0.05);治疗组治疗后的尿蛋白含量、血清血蛋白含量、血清肌酐酸含量、肾小球滤过率、VCAM-1含量趋于正常值,与治疗前比较差异有统计学意义(P<0.05);两组治疗后的尿蛋白含量、血清血蛋白含量、血清肌酐酸含量、肾小球过滤率、VCAM-1含量比较,差异有统计学意义(P<0.05);治疗组的总不良反应发生率为18.52%,对照组的总不良反应率为24.07%,两组比较差异无统计学意义(P>0.05)。结论来氟米特与糖皮质激素联合治疗进展性Ig A肾病的效果良好,更有助于进展性Ig A肾病患者的自身健康恢复,能明显降低VCAM-1水平,值得在临床上大力推广,具有显著医学价值和研究意义。
Objective To explore the Leflunomide combined with glucocorticoid on treating advanced IgA nephropathy and its influence on VCAM-1 level.Methods From March 2015 to January 2017,108 advanced IgA nephropathy patients treated in our hospital were selected as research objects.According to their different therapeutic time,they were evenly divided into the treatment group and the control group,54 cases in each group.In the treatment group,Lefluno- mide combined with glucocorticoid was used,while in the control group,Prednisolone was applied.The therapeutic effect, detection indicators like serum,etc.,and adverse reactions after treatment in the two groups were recorded.Results After treatment,the total effective rate was 92.59% in the treatment group,which was higher than that in the control group （75.98%） （P〈0.05）.After treatment,the urine protein content,serumalbumin content,serum creatinine content,glomerular filtration rate,and the level of VCAM-1 all tended to normal values,which were displayed statistical differences compared with before treatment （P〈0.05）.There was significant difference in the urine protein content,serumalbumin content,serum creatinine content,glomerular filtration rate,and the level of VCAM-1 between the two groups after treatment （P〈0.05）.The total adverse reaction rate in the treatment group was 18.52%,and 24.07% in the control group,there was no significant difference （P〉0.O5）.Conclusion Combination of Leflunomide and glucocorticoid in the treatment of progressive IgA nephropathy is effective,and it is helpful for the self-recovery of these patients and can greatly decrease VCAM-1 level.It is worthy to be promoted in clinical practice,which has a remarkable medical value and is of great significance.
出处
《中国当代医药》
2017年第31期80-82,共3页
China Modern Medicine
