摘要
目的对比分析新辅助化疗奥沙利铂+5-氟尿嘧啶+亚叶酸钙(FOLFOX)方案和5-氟尿嘧啶+顺铂(FP)方案对进展期胃癌的疗效。方法选取进展期胃癌患者87例,根据治疗方法不同将患者分为A组(新辅助化疗FOLFOX方案治疗,n=44)和B组(FP方案治疗,n=43)。比较两组患者的疗效和不良反应发生情况。结果两组患者的近期临床疗效及治疗总有效率比较,差异均无统计学意义(P﹥0.05);A组患者的骨髓抑制、周围神经反应发生率高于B组患者(P﹤0.05);A、B两组患者的手术情况及总手术切除率比较,差异均无统计学意义(P﹥0.05)。结论新辅助化疗FOLFOX方案与FP方案治疗进展期胃癌的疗效相当,且不良反应可以接受,值得临床推荐。
Objective To compare the efficacy of neoadjuvant chemotherapy FOLFOX regimen（oxaliplatin＋fluorouracil＋leucovorin） in comparison with the FP regimen（fluorouracil＋cisplatin） in the treatment of advanced gastric cancer.Method 87 patients with advanced gastric cancer were divided as group A（neoadjuvant chemotherapy FOLFOX regimen, n=44） and group B（FP regimen, n=43）. The efficacy and adverse reactions were observed and compared between the two groups. Result The short-term efficacy and overall response rate of the two groups were similar（P〉0.05）; higher incidence of bone marrow suppression and peripheral neurotoxicity was observed in group A compared to group B（P〈0.05）; the surgery measures and overall resection rate were of no significant difference between the two groups（P〉0.05）.Conclusion The neoadjuvant chemotherapy regimen FOLFOX may offer comparable efficacy compared to FP regimen,with acceptable incidence and severity of adverse reactions.
作者
张亚琨
孙颖
管燕
刘海新
ZHANG Yakun;SUN Ying;GUAN Yan;LIU Haixin(Department of Onco logy, East Division, Qingdao Municipal Hospital, Qingdao 266000, Shandong, China;Department of Internal Medicine, Shandong Provincial Cancer Hospital, Ji＇ nan 250117, Shandong, China;Department of Oncology, West Division, Qingdao Municipal Hospital, Qingdao 266000, Shandong, China)
出处
《癌症进展》
2017年第9期1029-1031,共3页
Oncology Progress
关键词
新辅助化疗
FOLFOX方案
FP方案
进展期胃癌
疗效
neoadjuvant chemotherapy
FOLFOX regimen
FP regimen
advanced gastric cancer
curative effect
