摘要
间皮素是一种细胞表面糖蛋白,正常组织中很少表达,但卵巢癌、胰腺癌和恶性间皮瘤等肿瘤组织及血液中高表达.因此,间皮素有助于间皮瘤、卵巢癌、胰腺癌等肿瘤的早期诊断,与肿瘤的分期和预后有关.使用抗毒素、抗间皮素嵌合抗体、抗体-药物结合物、嵌合抗原受体T细胞、间皮素肿瘤疫苗等治疗高表达间皮素的肿瘤的方法正在逐步走向成熟.旨在对间皮素在卵巢癌、胰腺癌、恶性间皮瘤诊断与治疗中的作用作一综述.
Mesothelin is a cell surface glycoprotein,with little expression in normal tissues, but highlyexpressed in tumors such as ovarian cancer,pancreatic cancer and malignant mesothelioma. Therefore, mesothelinhelps those tumors＇ early diagnosis, and is related to tumor staging and prognosis. The use of immunotoxin,anti-mesothelin chimeric antibodies, antibody-drug conjugates, chimeric antigen receptor T cells, mesothelintumor vaccines is progressing towards maturation in the treatment of mesothelin-rich tumors. This article aims toreview the research progress of mesothelin in ovarian cancer,pancreatic cancer, malignant mesothelioma diagnosisand treatment.
出处
《昆明医科大学学报》
CAS
2017年第9期134-139,共6页
Journal of Kunming Medical University
基金
国家自然科学基金资助项目(81160179
81160179)
云南省科技厅-昆明医科大学应用基础研究联合专项基金资助助目(2014FA013
2009ZC100M)
关键词
间皮素
可溶性间皮素相关蛋白或多肽
卵巢癌
恶性间皮瘤
胰腺癌
Mesothelin
Soluble mesothelin-related protein or peptide
Ovarian cancer
Malignantmesothelioma
Pancreatic cancer
