摘要
目的探讨眼眶恶性孤立性纤维性肿瘤(malignant solitary fibrous tumor,MSFT)的临床病理特点及鉴别诊断。方法对1例眼眶MSFT的临床表现、影像学、病理组织学变化及免疫表型进行分析,并结合相关文献进行讨论。结果肿瘤细胞弥漫分布,主要由梭形细胞构成,呈束状、波浪状、席纹状等不规则排列,其中散在畸形或多核瘤巨细胞,核分裂像易见;间质血管丰富,主要为薄壁分枝状鹿角样小血管,局部包膜侵犯。免疫组化染色显示肿瘤细胞表达CD34、Bcl-2和Vimentin,CD68、S-100、SMA、CD117、F8、Melan A、HMB45、CD31均阴性。结论发生于眼眶的MSFT是1种非常罕见的肿瘤,其临床表现及影像学均无特征性,明确诊断主要依靠病理组织学特征及免疫表型。
Objective To investigate the clinicopathological features and differential diagnosis of malignant solitary fi -brous tumor in orbit.Methods 1 case of MSFT in the orbit was analyzed by the clinical data analyses ,medical imaging ,HE stai-ning and immunohistochemistry of EnVision technique ,with review of the related literatures.Results Microscopially,the tumor cells were mainly composed of spindled and arranged in fascicular ,wavilness,storiform or patternless pattern.The misshapen cells and tumor giant cells were scattered in tumor cells and mitoses were obvious.Thin-walled vessels like staghorn were filled in inter-stitial.The focal capsular invasion was visible.Immunohistochemically ,the tumor cells were diffusely positive for CD 34,Bcl-2,and Vimentin,while negative for CD68,S-100,SMA,CD117,F8,Melan A,HMB45,CD31.Conclusion Obital MSFT is extremely rare.Its clinical feature and medical imaging are atypical.Its diagnosis mainly relies on its pathological morphology and immuno-histochemical profiles.
出处
《实用癌症杂志》
2017年第1期108-111,共4页
The Practical Journal of Cancer
关键词
孤立性纤维性肿瘤
恶性
病理组织学
免疫组化
鉴别诊断
Solitary fibrous tumor
Malignant
Histopathology
Immunohistochemistry
Differential diagnosis
