摘要
目的探讨中枢神经系统孤立性纤维瘤(cSFT)的病理学、影像学和临床特征,以及手术对其的治疗效果。方法自2003年3月至2007年2月共有28例cSFT瘤患者在我科手术治疗。对此28例cSFT患者的临床资料进行回顾性分析。结果本组cSFT患者的发病中位年龄39.5岁。cSFT起源于硬脑膜23例,非硬脑膜5例;良性肿瘤23例,非典型性5例。5例非典型性者CD34阴性表达或弱表达。磁共振T1多为等信号,T2多为混杂信号。全切21例;7例部分或次全切除,术后均行伽玛刀治疗。随访19例,全切14例无复发,5例部分切除预后不佳。结论cSFT多附着于大脑镰与小脑幕;非典型性肿瘤CD34阴性表达或弱表达;磁共振T2多为混杂信号,而T1多为等信号;肿瘤全切者预后较好;未全切肿瘤者术后伽玛刀放射治疗的效果尚不明确。
Objective To explore the diagnosis and treatment of solitary fibrous tumors of central nervous system （cSFTs）. Method The clinical data of 2S patients with cSFTs, who were surgically treated in our department from 2003 to 2007, were analyzed retrospectively. Results The patients＇ ages ranged from 22 to 67 years old （median age of 39.5 years）. Of 28 cases of cSFTs, 23 originated from the dura mater and 5 not. The cSFTs were pathologically diagnosed as benign tumors in 23 patients and atypical cSFTs in 5. The expression of CD34 was negative or weakly positive in 5 cases of atypical cSFTs. These lesions were mostly isointense on T1 weighted images and heterointensity on T2 weighted images. Of 28 patients with cSFTs, 21 received total resection of cSFTs and 7 subtotal or part. Gamma-knife stereoradiotherapy was performed in 7 patients with residual cSFTs after the operation. Of 19 patients followed up from 9 to 54 months, 14 had good prognosis and 5 bad due to subtotal or part resection of cSFTs. Conclusions cSFTs mostly originated from tbe cerebral falx or tentorium of cerebellum. MRI is helpful to the diagnosis of cSFTs, but it do not make a definete diagnosis of cSFl＇s, which can be definitely made by pathological examination and immunohistochemical staining. There are good prognoses in the patients with cSFTs after the total removal of cSFTs. The curatie effect of gamma-knife on cSFT was not definitive.
出处
《中国临床神经外科杂志》
2009年第1期1-3,共3页
Chinese Journal of Clinical Neurosurgery
关键词
孤立性纤维瘤
中枢神经系统免疫组织化学
诊断
治疗
Solitary fibrous tumor
Central nervous system
Immunohistochemistry
Diagnosis
Treatment
