摘要
目的通过检测子宫内膜异位症不同阶段血清CA125水平、组织P53和Bcl-2蛋白表达的变化,探讨其在子宫内膜异位症癌变预测和诊断中的应用价值。方法选择子宫内膜异位症癌变患者12例(癌变组),卵巢子宫内膜不典型增生患者16例(增生组)和卵巢子宫内膜异位症患者25例(内异症组),检测3组患者血清中CA125的水平及组织中P53、Bcl-2蛋白表达。结果癌变组和增生组的血清CA125水平比内异症组各期均显著增高,且癌变组显著高于增生组,内异症组随着严重程度的增加,血清CA125水平逐渐升高;癌变组P53蛋白的表达显著高于增生组和内异症组,增生组与内异症组之间无统计学差异;Bcl-2蛋白在癌变组和增生组中的阳性表达率较高,与内异症组相比均有统计学差异,癌变组和增生组之间比较无统计学差异。癌变组中P53蛋白在癌变区的阳性表达率显著高于移行区和内异区,Bcl-2蛋白在不同区域中的表达无统计学差异。结论血清CA125水平过高、组织中P53、Bcl-2蛋白的高阳性表达率均是提示子宫内膜异位症发生癌变的指标,可用于早期预测和诊断子宫内膜异位症癌变。
Objective To detect the changes of serum CA125,Bcl-2 and P53 protein expression in different stages of en-dometriosis,and to explore its application value in the diagnosis of endometriosis.Methods 12 cases of ovarian endometriosis with malignant transformation ,16 cases of ovarian endometrial atypical hyperplasia and 25 cases of ovarian endometriosis were se-lected.Serum level of CA125 and P53 and Bcl-2 protein expression in the tissues were detected.Results The serum CA125 level of cancer group and hyperplasia group significantly increased ,and cancer group was significantly higher than that of hyperplasia group.With increasing severity of endometriosis group ,serum CA125 levels gradually increased.The expression of P53 protein in carcinoma group was significantly higher than that of hyperplasia group and endometriosis group ,there had no significant differ-ence between hyperplasia group and endometriosis group;Comparing with endometriosis group ,there was a higher rate of positive expression of Bcl-2 protein in the cancer group and hyperplasia.No significant difference between carcinoma group and hyperplasi-a group;P53 protein in cancer group of positive expression rate in cancerous area was significantly higher than that of the transi -tional zone and EMS region ,the expression of Bcl-2 protein in different regions had no significant difference.Conclusion The high positive rate of P53,Bcl-2 and high serum level of CA125 are the indicators of the occurrence of malignant transformation of endometriosis ,which can be used for early prediction and diagnosis of the malignant transformation of endometriosis.
出处
《实用癌症杂志》
2017年第1期21-23,共3页
The Practical Journal of Cancer
