摘要
目的探讨阿魏酸钠联合常规综合治疗对伴高血脂急性心肌梗死（AMI）患者血液流变学、血清Gas6（生长停滞特异性基因产物6）、Hcy（同型半胱氨酸）水平的影响。方法以本院心内科收治的168例高血脂伴AMI患者为研究对象，根据是否使用阿魏酸钠分为常规组与观察组，常规组人院后均予以吸氧、硝酸酯类药物扩张冠脉、维持水电平衡等常规综合治疗，观察组在综合治疗基础上加用阿魏酸钠，总疗程14d，疗程结束后观察两组治疗前后的血液流变学指标（全血粘稠度、纤维蛋白原、红细胞压积），并观察血清Gas6、Hcy及LDL—C、TC等指标。结果常规组总有效率为76．O％，明显低于观察组的88．17％，组间差异有统计学意义（P〈0．05）；治疗后常规组全血粘稠度为（4．31±0．27）mPa，纤维蛋白原为（2．35±0．43）g／L，红细胞压积为（1．52±0．26）％，观察组依次是（4．08±0．24）mPa、（2．03±0．32）g，L、（1．32±0．16）％，两组各指标较治疗前均显著下降，且观察组各指标明显低于对照组，组间差异均有统计学意义（均P〈0．05）；治疗后常规组血清Gas6为（14．35±2．25）ng／ml，Hcy为（16．25±2．34）μmol／L，LDL—C为（2．75±0．72）mmol／L，TC为（4．45±0．58）mmol／L，均显著高于观察组的（13．37±1．86）ng／ml、（14．53±2．05）μmol／L、（2．15±0．64）mmol／L、（3．59±0．74）mmol／L，组问差异均有统计学意义（P〈0．05）。结论阿魏酸钠联合常规综合治疗可显著改善高血脂伴急性心肌梗死患者血液流变学，同时降低Gas6、Hey及血脂水平，具有重要临床研究意义。
Objective To investigate the effect of sodium ferulate combined with routine comprehensive treatment on hemorheology, serum levels of growth arrest specific gene product 6 （Gas6） and homocysteine （Hey） in patients with acute myocardial infarction （AMI） and hyperlipidemia. Methods A total of 168 patients with hyperlipidemia and AMI treated our hospital were enrolled into the study and were divided into a routine group and an observation group according to whether they were treated with sodium ferulate. The routine group were given routine comprehensive treatment. On the basis of routine comprehensive treatment, the observation group were treated with sodium ferulate. All the patients were treated for 14 days. After the treatment, the hemorheological indexes （whole blood viscosity, fibrinogen, and hematocrit） and serum levels of Gas6, Hcy, LDL-C, and TC in the two groups were observed before and after the treatment. Results The total effective rate was significantly lower in the routine group than t in the observation group （76.0% vs. 88.17%, P〈0.05）. After the treatment, the whole blood viscosity, fibrinogen, and hematocrit in the two groups were significantly decreased and were lower in the observation group than in the control group （all P〈0.05）. After the treatment, the serum levels of Gas6, Hcy, LDL-C, and TC were significantly higher in the routine group than in the observation group [ （ 14.35±2.25 ） ng/mL, （16.25±2.34） μmol/L, （2.75±0.72） mmol/L, and （4.45±0.58） mmol/L vs. （13.37±1.86） ng/ mL, （14.53±2.05） μmol/L, （2.15±0.64） mmol/L, and （3.59±0.74） mmol/L] （P〈0.05）. Conclusion Sodium ferulate combined with routine comprehensive treatment can significantly improve the hemorheology and reduce the levels of Gas6, Hcy, and blood lipids in patients with hyperlipidemia and AMI.
出处
《国际医药卫生导报》
2017年第21期3401-3404,共4页
International Medicine and Health Guidance News
关键词
阿魏酸钠
高血脂
心肌梗死
血液流变学
临床疗效
Sodium ferulate
Hyperlipidemia
Myocardial infarction
Hemorheology
Curative effect
