摘要
目的:分析氯吡格雷联合阿司匹林治疗急性心肌梗死的临床效果。方法:选择在我院收治的100例急性心肌梗死患者,分为氯吡格雷组与联合治疗组(氯吡格雷联合阿司匹林),各50例。两组均在常规药物治疗基础上采用上述不同治疗方案。疗程4周,比较两组患者的治疗总有效率、血小板聚集率、冠状动脉再通时间、凝血酶原时间、左心室射血分数以及住院期间心血管事件发生率等指标。结果:联合治疗组临床治疗总有效率明显高于氯吡格雷组(96.00%比80.00%,P=0.014);治疗后,与氯吡格雷组比较,联合治疗组患者的血小板聚集率[(47.63±7.83)%比(38.45±8.55)%]及心血管事件发生率(24.00%比4.00%)显著降低,冠状动脉再通时间[(45.44±4.42)比(41.93±5.85)]显著缩短,左心室射血分数[(48.56±5.79)%比(55.51±6.44)%]显著提高(P均<0.01)。结论:氯吡格雷联合阿司匹林治疗急性心肌梗死的临床效果显著。
Objective：To comprehensively analyze therapeutic effect of clopidogrel combined aspirin on acute myocardial infarction（AMI）.Methods：A total of 100 AMI patients treated in our hospital were selected,and equally divided into clopidogrel group and combined treatment group（received clopidogrel combined aspirin）.Both groups received routine treatment for 4 weeks.Total effective rate,platelet aggregation rate（PAR）,coronary recanalization time,prothrombin time（PT）,left ventricular ejection fraction（LVEF）and incidence rate of cardiovascular events during hospitalization were compared between two groups.Results：Total effective rate of combined treatment group was significantly higher than that of clopidogrel group（96.00% vs.80.00%,P=0.014）.Compared with clopidogrel group after treatment,there were significant reductions in PAR [（47.63±7.83）% vs.（38.45±8.55）%],incidence rate of cardiovascular events（24.00%vs.4.00%）and coronary recanalization time[（45.44±4.42）vs.（41.93±5.85）],P and significant rise in LVEF[（48.56±5.79）% vs.（55.51±6.44）%]in combined treatment group,P〈0.01 all.Conclusion：The clinical effect of clopidogrel combined with aspirin in the treatment of acute myocardial infarction is significant.
作者
金朝霞
万里鹏
覃艳琼
JIN Zhao-xia; WAN Li-peng; QIN Yan-qiong(Department of Cardiology, Central Hospital of Huanggang City, Hnanggang, Hubei, 438000, China)
出处
《心血管康复医学杂志》
CAS
2018年第5期554-557,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
心肌梗死
阿司匹林
氯吡格雷
Myocardial infarction
Aspirin
Clopidogrel
