摘要
目的探讨尿酸转运蛋白相关基因单核苷酸多态性与原发性痛风的相关性。方法检索Pub Med数据库、EMBASE数据库、中国知网数据库和万方数据库的相关中英文文献,收集尿酸转运蛋白相关基因多态性与原发性痛风易感性的相关研究,按纳入与排除标准筛选文献,提取资料。使用Rev Man 5.3软件进行荟萃统计分析,敏感性分析及发表偏倚分析。结果共10 386例原发性痛风患者和21 076例对照者纳入分析,荟萃分析结果显示,SLC2A9 rs3733591[OR(95%CI)=0.76(0.66,0.89),P<0.05]、SLC2A9rs16890979[OR(95%CI)=0.33(0.18,0.58),P<0.05]、SLC2A9 rs6855911[OR(95%CI)=0.66(0.56,0.77),P<0.05]、SLC2A9rs13124007[OR(95%CI)=1.49(1.17,1.91),P<0.05]、SLC2A9 rs1014290[OR(95%CI)=0.69(0.53,0.89),P<0.05]和ABCG2rs2231142[OR(95%CI)=2.13(1.81,2.50),P<0.05]这六个位点的多态性与原发性痛风易感性相关。结论 SLC2A9(rs3733591、rs16890979、rs6855911、rs13124007和rs1014290)和ABCG2(rs2231142)的多态性与原发性痛风易感性相关。
Objective To assess the association of uric acid transporter protein gene single nucleotide polymorphisms with the risk of primary gout. Methods Studies on uric acid transporter-related gene polymorphisms with primary gout were searched in PubMed, EMBASE, CNKI and China Wanfang literature databases. Information was extracted according to inclusion and exclusion criteria. REVMAN 5.3 software was applied to perform meta-analysis, sensitivity analysis and publication bias analysis. Results Total 10,386 cases and 21,076 controls were included for the current meta-analyses. The results showed that SLC2A9 rs3733591 （OR=0.76, 95%C/： 0.66, 0.89, P〈0.05）, SLC2A9 rs16890979 （OR = 0.33, 95%C/： 0.18, 0.58, P〈0.05）, SLC2A9 rs6855911（OR=0.66, 95%C/： 0.56, 0.77, P〈0.05）, SLC2A9 rs13124007（OR=1.49, 95%C/： 1.17, 1.91, P〈0.05）, SLC2A9 rs1014290 （OR=0.69, 95%C/： 0.53, 0.89, P〈0.05） and ABCG2 rs2231142（OR=2.13, 95%C/： 1.81, 2.50, P〈0.05） were significantly associated with the risk of primary gout. Conclusion Our results showed six genetic variants SLC2A9 rs3733591, rs16890979, rs6855911, rs13124007, rs1014290 and ABCG2 rs2231142 are significantly associated with primary gout.
作者
应颖
黄海燕
邹荣鑫
李晓可
陈勇
YING Ying HUANG Haiyan ZOU Rongxirt et al(Department of Rheumatology, Ningbo Second Municipal Hospital, Ningbo 315010, China)
出处
《浙江医学》
CAS
2017年第20期1763-1770,1777,共9页
Zhejiang Medical Journal
基金
浙江省医药卫生基金项目(2015KYB346
2017KY589)
