摘要
目的:分析药品微生物验证枯草芽孢杆菌实验菌液制备方法。方法:选择2016年7月-2016年12月作为研究阶段,以复方氨酚烷胺胶囊、银翘解毒颗粒以及板蓝根颗粒等能够对枯草芽孢杆菌产生抑制作用的6种药物作为研究对象,通过回收实验,检验枯草芽孢杆菌菌液制备方法。结果:通过对菌液及孢子菌液对相同受检药物进行回收试验,提示回收率差异不大,但孢子菌液回收率稍高(P?0.05)。结论:枯草芽孢杆菌的菌液及孢子菌液均可对药物微生物进行验证,但应用孢子菌液验证结果更好。
Objective： To analyze the method of preparing bacillus subtilis experimental bacteria fluid for drug microbiological verification. Methods： Selecting July 2016 -December 2016 as the research stage, Compound paracetamol and amantadine hydrochloride capsules, Yinqiaojiedu Granules and Banlangen Granules etc. 6 drugs that can produce inhibitory effect for Bacillus subtilis as the research objects, through the recovery experiment, Bacillus subtilis bacteria liquid preparation method was tested. Results： The same tested drug was recovered by the bacteria fluid and spore fluid for test, suggesting that the recovery rate is insignificant, but the spores liquid recovery rate is slightly higher （P〉0.05）. Conclusion： Both the bacteria liquid and spore fluid of Bacillus subtilis can be used to validate the drug microorganism, but the result is better by using spore liquid.
出处
《黑龙江医药》
CAS
2017年第4期716-718,共3页
Heilongjiang Medicine journal
