摘要
人的胃肠道内寄居着种类繁多的微生物,这些微生物称为肠道菌群。它们与人体功能代谢和免疫系统共同进化,在维持系统平衡中至关重要。正常情况下,肠道菌群按一定的比例组合,各菌间互相制约,互相依存,在质和量上形成一种生态平衡。当肠道菌群紊乱时,机体内环境发生变化,这种平衡状态被打破,并导致免疫应答、代谢的改变和各种疾病的发生。风湿性疾病是一组侵犯关节、骨骼、肌肉、血管及有关软组织或结缔组织为主的疾病,其病因复杂多样,研究显示其与感染性、免疫性、代谢性、内分泌性、退行性、地理环境性、遗传性、肿瘤性等因素密切相关。有研究发现,肠道菌群紊乱可增加类风湿关节炎(RA)、系统性红斑狼疮(SLE)等风湿性疾病的患病风险,且与其发生发展也有着密切的关系。本文就近年肠道菌群紊乱在风湿性疾病中的研究进展做一综述。
The gastrointestinal tract is home for wide variety of microbes,and known as intestinal flora.They have evolved with the body＇s metabolic and immune systems,which are crucial in maintaining the balance of the system.At the normal,the intestinal flora is combined with a certain proportion and the bacteria are mutually restricted and interdependent,forming an ecological balance in quality and quantity.When intestinal flora is disturbed,the internal environment changes and the balance is broken,resulting the immune response,metabolic changes and the occurrence of various diseases.Rheumatoid disease is a group of infringement of joints,bones,muscles,blood vessels and related soft tissue or connective tissue disease,its etiology is complicated,many study shows its and is infectious,autoimmune and metabolic,secretory,degenerative,geographical environment,genetic,tumor and other closely related.Studies have found that intestinal flora disorder increases the risk of rheumatoid arthritis（RA）and systemic lupus erythematosus（SLE）,and its also have a close relationship with the disease development.This paper reviews the progress of intestinal flora disorders in rheumatic diseases.
出处
《西部医学》
2017年第11期1629-1632,共4页
Medical Journal of West China
关键词
肠道菌群
菌群紊乱
风湿性疾病
Gut microflora
Gut microflora disturbance
Rheumatic disease
