摘要
目的探讨术前血浆D二聚体(D-D)水平与浆液性卵巢癌患者一线化疗疗效及远期生存率的关系。方法选择2012年1月至2014年1月收治的127例浆液性卵巢癌患者进行回顾性分析,所有患者均接受手术治疗。根据患者术前D-D水平分为正常组(D-D≤0.3 mg/L)81例、高水平组(D-D>0.3 mg/L)46例。对比两组患者的化疗疗效、远期生存率。结果高水平组的近期CR率41.30%显著的低于正常组的65.42%(P<0.05),高水平组的3年生存率、中位生存时间显著的低于正常组,差异具有统计学意义(P<0.05)。对127例浆液性卵巢癌患者进行Cox比例生存分析,结果显示FIGO分期(OR=1.398)、肿瘤低分化(OR=1.772)、淋巴结转移(OR=1.520)、D-D高水平(OR=1.297)是患者远期预后不良的独立危险因素(P<0.05);而年龄、病灶最大径对患者的远期生存影响不显著(P>0.05)。结论术前高血浆D-D水平对浆液性卵巢癌患者一线化疗近期疗效、远期预后具有不良影响。
Objective To investigate the relationship between preoperative plasma D two polymer（ D-D） level and long-term survival rate in patients with serous ovarian cancer. Methods From January 2012 to January 2014,127 cases of serous ovarian cancer patients treated in hospital oncology were selected,who performed surgery. According to preoperative DD,they were divided into 81 cases of normal group（ DD≤0. 3 mg/L）,46 cases of high-level group（ DD 0. 3 mg/L）. The effect of chemotherapy and long-term survival were analyzed. Results Recently CR rate of in high level（ 41. 30%） was significantly lower than that of the normal group（ 65. 42%）（ P〈0. 05）,3-year survival rate of normal group,median survival time were significantly higher than those of the high level group（ P〈0. 05）. Cox proportional survival analysis results showed that FIGO stage（ OR = 1. 398）,poorly differentiated tumors（ OR = 1. 772）,lymph node metastasis（ OR = 1. 520）. DD high level（ OR = 1. 297） was independent risk factor for patients with poor long-term prognosis（ P〈0. 05）. The patient＇s age,maximum diameter of lesions were not the impact of long-term survival of patients（ P〉0. 05）. Conclusion Preoperative plasma levels of D-D in patients with serous ovarian cancer can nfluence the chemotherapy curative effect and long-term prognosis.
出处
《临床和实验医学杂志》
2017年第21期2155-2158,共4页
Journal of Clinical and Experimental Medicine
关键词
浆液性卵巢癌
D二聚体
化疗
生存率
Serous ovarian cancer
D - dimer
Chemotherapy
Survival
