摘要
目的研究上皮性卵巢癌患者的凝血功能并探讨其临床意义。方法用磁珠法测定74例卵巢癌和48例良性卵巢肿瘤患者的纤维蛋白原(FIB)含量、凝血酶原时间(PT)、凝血酶时间(TT)和活化部分凝血活酶时间(APTT);采用BeckmanCoulter机计数血小板(PLT);电化学发光法检测癌抗原125(CA125)。结果上皮性卵巢癌患者的FIB为(4.29±2.01)g?L,PLT为(248.53±86.66)×109?L,较良性卵巢肿瘤患者(2.94±0.60)g?L、(177.90±49.87)×109?L明显升高(t=-4.513,-5.142;均P<0.01);上皮性卵巢癌患者的PT、TT及APTT分别为(13.40±0.95)、(16.93±2.34)、(38.62±6.22)s,与良性卵巢肿瘤患者比较(13.04±0.63)、(16.98±1.16)、(37.66±3.78)s差别无显著性意义(均P<0.01);Ⅲ+Ⅳ期卵巢癌患者FIB(4.62±2.26)g?L和PLT(273.35±87.09)×109?L较Ⅰ+Ⅱ期卵巢癌患者(3.62±1.17)g?L、(198.88±61.77)×109?L明显升高(t=-2.132、-3.892,均P<0.05),而PT、TT及APTT分别为(13.49±0.96)、(16.69±1.87)、(39.59±6.69)s与Ⅰ+Ⅱ期卵巢癌患者(13.22±0.91)、(17.70±3.07)、(36.68±4.70)s比较差别无显著性意义(均P>0.05);低分化卵巢癌患者FIB含量(4.63±2.24)g?L较高、中分化癌患者(3.65±1.28)g?L明显升高(t=-2.091,P<0.05),而PT、TT、APTT及PLT的含量分别为(13.43±0.88)、(16.70±1.80)、(39.63±6.59)s及(255.94±97.59)×109?L与高、中分化患者(13.36±1.08)、(17.36±3.12)、(36.72±5.04)s及(234.52±60.14)×109?L比较差别均无显著性意义(均P<0.05);卵巢癌患者血清CA125与PT、FIB呈显著正相关(r=0.306,P<0.01;r=0.229,P<0.05),而与TT、APTT及PLT之间无相关性(r=-0.054、0.130、0.198,均P>0.05)。结论上皮性卵巢癌患者FIB和PLT含量升高,血凝功能的测定有助于卵巢良恶性肿瘤的鉴别并可预测卵巢癌的一些不良生物学行为,抗凝治疗应作为卵巢癌患者综合治疗的方法之一。
Objective To investigate the blood coagulation and its significance in ovarian carcinoma. Methods STR-R automated coagulation analyzer was used in monitoring PT TT APTT and FIB in 74 patients with ovarian carcinoma and 48 patients with benign ovarian tumor. PLT was measured by Beckman Counter,CA125 was measured by chemiluminescence method. Results The levels of FIB and PLT were significantly elevated in patients with ovarian carcinoma compared to patients with benign ovarian tumor(4.29±2.01)g L vs (2.94±0.60)g L (248.53±86.66)×109 L vs (177.90±49.87)×109 L t=-4.513 -5.142均P<0.01),but there were no significantly differences in values of PT TT and APTT between cancer patients13.40±0.95)、(16.93±2.34) and (38.62±6.22)and benign tumor patients(13.04±0.63)(16.98±1.16) and (37.66±3.78). Patients with stage Ⅲ+Ⅳ had higher FIB(4.62±2.26g L) or PLT(273.35±87.09)×109 L levels than those with stage Ⅰ+Ⅱ(3.62±1.17)g L and (198.88±61.77)×109 L)(t=-2.132P<0.05 t=-3.892 P<0.01),but there were no significantly differences on the values of PT TT and APTT between stage Ⅲ+Ⅳ patients(13.49±0.96 16.69±1.87 and 39.59±6.69)and stage Ⅰ+Ⅱ patients(13.22±0.91)(17.70±3.07)and (36.68±4.70). Patients with poorly differentiated G3 ovarian carcinoma had higher FIB level than those with well differentiated diseases G1+G2(4.63±2.24) g L vs (3.65±1.28)g L (t=-2.091 P<0.05 ,but there were no significantly differences on the values of PT TT APTT and PLT between G3 patients and G1+G2 patients(13.43±0.88)vs (13.36±1.08) (16.70±1.80) vs (17.36±3.12)(39.63±6.59) vs (36.72±5.04)(255.94±97.59)×109 L vs (234.52±60.14)×109 L). Moreover there were positive correlations between CA125 and PT FIB(r=0.306 P<0.01 r=0.229 P<0.05),but there were no correlations between CA125 and TT APTT PLT. Conclusion The levels of FIB and PLT were elevated in patients with ovarian carcinoma. The measurement of blood coagulat
出处
《浙江医学》
CAS
2005年第7期490-492,共3页
Zhejiang Medical Journal
