摘要
目的探讨血清胱抑素(Cys C)、降钙素原(PCT)及N末端前体脑钠肽(NT-pro BNP)水平与脓毒血症疾病严重程度的相关性。方法前瞻性选取105例脓毒血症患者作为研究对象,全部患者根据病情严重程度的不同分为三组,同时选取门诊的35例健康体检者作为对照组。测定各组患者的APACHEⅡ评分,采用免疫化学发光法测定PCT水平,采用酶联免疫吸附法测定Cys C和NT-pro BNP水平。比较对照组和三组患者的Cys C,PCT和NT-pro BNP水平差异,应用Pearson相关性分析法分析三者与APACHE-Ⅱ评分的相关性。结果脓毒血症患者的病情由一般至严重、休克进展时,APACHE-Ⅱ评分随之升高。各组脓毒血症患者的血清Cys C、PCT和NT-pro BNP水平均显著高于对照组(P<0.05),随脓毒血症患者的病情由一般至严重、休克进展时,Cys C、PCT和NT-pro BNP水平均显著升高,差异均有统计学意义。血清Cys C、PCT和NT-pro BNP水平与APACHE-Ⅱ评分呈显著正相关关系(r=0.566,0.613,0.627,P<0.01)。结论血清Cys C、PCT和NT-pro BNP水平与脓毒血症患者的病情程度密切相关,可以作为预估病情的指标。
Objective To study the relationship between serum cystatin,reduced procalcitonin and N terminal pro brain natriuretic peptide and severity of sepsis. Methods A total of 105 cases of sepsis patients were selected as the research object,which were divided into 3 groups： sepsis group,severe sepsis group and septic shock group according to the severity of the disease. 35 cases of healthy persons were selected as control group. APACHE score of all the patients were determined,PCT level was determined by immune chemiluminescence method,CysC and NT-proBNP were determined by enzyme linked immunosorbent assay. The level of CysC,PCT and NT-proBNP of the control group and the three groups of patients were compared. Pearson correlation analysis was used to analysis the correlation between PCT and CysC,NT-proBNP level and APACHE-score. Results With the aggravation of sepsis,APACHE score of the patients increased significantly. The serum CysC,PCT and NT-proBNP of the general sepsis group,severe sepsis group and septic shock group were significantly higher than those in the control group.The serum CysC,PCT and NT-proBNP of the septic shock patients were significantly higher than those in the severe sepsis group. The serum CysC,PCT and NT-proBNP of thesevere sepsis patients were significantly higher than those in the general sepsis group. There was a significant positive correlation between CysC,PCT and NT-proBNP levels and APACHE score（ r = 0. 566,0. 613,0. 627,P 〈0. 01）. Conclusion The serum level of CysC,PCT and NT-proBNP are closely related to the severity of disease and sepsis patients,which can be used as predictive indicators of condition.
出处
《临床和实验医学杂志》
2017年第21期2137-2139,共3页
Journal of Clinical and Experimental Medicine
