摘要
目的:旨在使用Meta分析方法系统评价八聚体结合转录因子4(octamer-binding transcription factor 4,OCT4)表达与非小细胞肺癌(non-small cell lung cancer,NSCLC)临床病理特征的关系。方法:电子检索Pub Med、Embase、中国生物医学文献数据库、中国学术期刊全文数据库、维普中文科技核心全文数据库以及万方数据库,检索时间从建库至2016年3月,查找涉及OCT4表达与NSCLC临床病理特征相关的病例对照研究。参照Cochrane协作网推荐的方法进行筛选及提取数据并评价纳入研究的质量,运用Revman 5.2软件及Stata 12.0软件进行Meta分析。结果:共纳入10个研究,905例患者。OCT4阳性组471例,OCT4阴性组434例。Meta分析结果显示,OCT4阳性表达与肺腺癌(OR=1.75,95%CI=1.22~2.53,P=0.003)、低分化癌(OR=2.93,95%CI=1.25~6.84,P=0.010)、中分化癌(OR=1.81,95%CI=1.12~2.94,P=0.020)、T3/T4期肿瘤(OR=1.95,95%CI=1.10~3.45,P=0.020)、术后生存期短(鳞癌:MD=-4.49,95%CI=-7.73^-1.55,P=0.003;腺癌:MD=-8.52,95%CI=-9.82^-7.23,P=0.000)及总体生存率低下(HR=1.99,95%CI=1.52~2.60)关系较为密切,差异均具有统计学意义。结论:OCT4阳性表达与肺腺癌、NSCLC恶性特征以及预后不良密切相关,可以为肺癌靶向治疗提供可靠的科学依据。
Objective：To evaluate the association of octamer-binding transcription factor 4 （OCT4） positive expressions with clinic- pathological characteristics of non-smaU cell lung cancer（NSCLC） by using meta-analysis. Methods：Case-control studies published until March 2016 involving the correlation between OCT4 and clinic-pathological features of NSCLC were electronically searched in PubMed, Embase, CNKI, VIP and Wanfang database. Two reviewers independently screened the articles, extracted the data and evalu- ated the quality of the selected articles based on the recommendation of Cochrane collaboration. And Meta^analysis was performed by using Revman 5.2 and Stata 12.0 software. Results ：Ten articles containing 796 cases among which there were 471 cases in OCT4 positive group and 434 cases in OCT negative group were included. Meta results showed that positive expressions of OCT4 had close correlations with adenocarcinoma （OR = 1.75,95% CI= 1.22 to 2.53, P=0.003 ）, poor differentiation （OR =2.93,95% CI= 1.25 ~6.84, P= 0.010） ,moderate differentiation（OR=1.81,95%CI=1.12 to 2.94,P=0.020）,T3/T4 stage of primary tumor（OR=1.95,95%Cl=1.10 to 3.45, P=0.020 ） and short postoperative lifetime （ squamous cell carcinoma： MD=-4.49,95%CI=-7.73 to - 1.55, P=0.003; adenocarcinoma： MD=-8.52,95 %CI=-9.82 to -7.23, P=0.000）, and low overall survival rate （ HR = 1.99,95% CI= 1.52 to 2.60）, all differences were sta- tistically significant. Conclusion：Positive expressions of OCT4 may be associated with adenocarcinoma, malignant features of NSCLC and poor prognosis, which can provide reliable scientific evidence for targeted therapy.
出处
《重庆医科大学学报》
CSCD
北大核心
2017年第11期1438-1443,共6页
Journal of Chongqing Medical University
