摘要
流行病学研究显示,胃癌患者中约89%的非贲门部胃癌由幽门螺杆菌(Helicobacter pylori,Hp)感染所致然而,尽管目前已有大量相关研究证实,Hp对人体消化道造成损害的主要原因是其毒性基因生成相应毒素而致,但其在胃癌发生及发展中的作用机制尚不明确。为此,笔者通过查阅中外文献,汇总分析了Hp在胃癌发病机制中的最新研究成果,总结了Hp与胃癌相关性的最新研究进展,旨在为Hp感染与胃癌发病机制关系的进一步研究提供思路与帮助。
Epidemiologic studies showed that among all patients with gastric cancer, about 89% non-cardia gastric cancers are caused by helicobacter pylori （ Hp ） infection. However, although a large number of relevant studies have con- firmed that the Hp can cause damage to our digestive tract because its toxic gene produces toxin, the mechanism of action of Hp in the occurrence and development of gastric cancer remains unclear. To this end, the author reviewed Chinese and for- eign literatures, analyzed the latest researches on the role of Hp in the pathogcnesis of gastric cancer and summarized the progress of research on the correlation between Hp and gastric cancer. By doing so, the author intends to offer some thoughts for the research on the relationship between Hp infection and the pathogenesis of gastric cancer.
出处
《中国烧伤创疡杂志》
2017年第5期340-344,共5页
The Chinese Journal of Burns Wounds & Surface Ulcers
基金
2014年国家自然科学基金项目(项目编号:314600232014)~~
关键词
幽门螺杆菌
胃癌
发病机制
研究进展
综述
Helicobacter pylori
Gastric cancer
Pathogenesis
Research progress
Review
