摘要
目的通过分析少关节起病类风湿关节炎(rheumatoid arthritis,RA)的临床特点,以提高对该病的全面认识和诊治水平。方法回顾性分析和总结198例RA患者的临床和实验室资料,98例少关节起病RA为观察组,100例多关节起病RA为对照组。结果观察组男性多于对照组(t=2.456,P=0.015);病程短于对照组(t=-2.450,P=0.018);关节受累数少于对照组(t=-6.316,P<0.001);晨僵发生率少于对照组(t=-3.884,P<0.001);28个关节疾病活动性评分低于对照组(t=-8.694,P<0.001);而抗环瓜氨酸抗体阳性率高于对照组(t=-2.299,P=0.022);促甲状腺激素水平高于对照组(t=3.809,P<0.001)。两组在年龄、血沉及C反应蛋白、免疫球蛋白及补体水平、游离三碘甲状腺原氨酸、血清游离甲状腺素、血脂、血液系统及肝肾受累方面的差异无统计学意义(均有P>0.05)。结论少关节起病RA临床表现不典型,可能为疾病的早期表现;并发亚临床甲减不少见,值得重视。
Objective To improve the comprehensive understanding and treatment level of the disease by analyzing the clinical characteristics of rheumatoid arthritis （RA） caused by pauciarticular arthritis.Methods The method was retrospective analysis and summary of clinical and laboratory data of 198 cases of patients with RA,in which 98 cases of pauciarticular arthritis belonged to the observation group and 100 cases of polyarticular arthritis belonged to the control group.Results Male patients in observation group were obviously more than those in the control group （t =2.456,P =0.015）.Courses of disease was obviously shorter than those in the control group （t =-2.450,P =0.018）.The number of involved joints was obviously less than those in the control group （t =-6.316,P 〈0.001）.The incidence of morning.stiffness was significantly less than those in the control group （t =-3.884,P 〈 0.001）.Rating scores of disease activity score 28 were significantly lower than those in the control group （t =-8.694,P 〈 0.001）.And positive rate of anti-cyslic citrullinated peptide antibody is significantly higher than those in the control group （t =-2.299,P =0.022）.Thyrotrophin levels were significantly higher than those in the control group （t =3.809,P 〈 0.001）.There was no significant differences in age,erythrocyte sedimentation rate and C reactive protein,immunoglobulin and complement level,free triiodothyronine,free thyroxine,blood lipids,blood system and kidney involvement between the two groups （all P 〉 0.05）.Conclusions The conclusion turns out to be that there are no typical clinical manifestations showing that rheumatoid arthrifts is caused by pauciarticular arthritis.Maybe it is the early performance of disease.It is worth attention that concurrent subclinical hypothyroidism turns out to be more.
作者
王斌
陈竹
李向培
郭兆军
WANG Bin;CHEN Zhu;LI Xiang-pei;GUO Zhao-jun(Department of Rheumatology, Huainan 1st Municipal People＇ s Hospital, Huainan 232007, China;Department of Rheumatology , the Affiliated Provincial Hospital of Anhui Medical University, Heifei 230001, China)
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2017年第9期935-938,共4页
Chinese Journal of Disease Control & Prevention
基金
安徽省自然科学基金面上项目(1608085MH172)
关键词
关节炎
类风湿
关节
流行病学方法
Arthritis,rheumatoid
Joint
Epidemiologic methods
