摘要
目的探讨氯米芬（clomipheriecitrate，CC）／促性腺激素（Gn）方案中，对卵巢储备低下患者在促排卵早期添加来曲唑（I_etrozole，LE）对体外受精一胚胎移植（IVF-ET）结局的影响。方法回顾性分析了采用CC／Gn方案行IVF-ET卵巢储备低下患者273例，共323个治疗周期，依据促排卵早期是否使用LE的情况分为LE组、非LE组。结果LE组与非LE组相比较，在启动日激素、卵泡数、获卵数、正常受精数，率、可用胚胎数，率、优胚数，率方面差异均无统计学意义（均P〉0．05）；非LE组HCG日雌二醇（E2）、黄体酮（P），Gn天数、Gn总量高于LE组，差异均有统计学意义（均P〈0．05）。LE组与非LE组相比较总妊娠率、分娩或继续妊娠率、流产率、宫外孕率的差异均无统计学意义（均P〉0．05）；LE组生化妊娠率高于非LE组，差异有统计学意义（P〈0．05）。结论在CC／Gn方案中，卵巢储备低下患者中促排卵早期添加LE能够减少Gn使用量及使用时间，提高Gn使用效率，生化妊娠率有所升高。
Objective To investigate the influence of letrozole （LE） administration upon the outcome of in vitro fertilization - embryo transfer （IVF-ET） with CC/Gn protocol in patients with poor ovarian reserve. Methods 273 patients with poor ovarian reserve undergoing 323 IVF-ET cycles with CC/Gn protocol were analyzed retrospectively. According to administration of LE, they were divided into Group LE and Group non- LE. Results The level of hormone and count of follicles on the day of starting, the count of oocytes retrieved, the count/rate of normal fertility, available embryo, and high-quality embryo were not significantly different between the two groups （P〉0.05）. E2, P on the day of HCG, the days and total amount of Gn in Group non-LE were significantly higher than those in Group LE （t〈0.05）. There were no statistically significant differences between the two groups in the total pregnancy rate, delivery and continued pregnancy rate, abortion rate, ectopic pregnancy rate （t＇〉0.05）, but chemical pregnancy rate in Group LE was significantly higher than that in Group non-LE （P〈0.05）. Conclusion The administration of LE in patients with poor ovarian reserve of IVF-ET with CC/Gn protocol can contribute to reduce the total amount and days of Gn and improve the efficiency of Gn, with higher chemical pregnancy rate.
作者
陈希曦
黎淑贞
黎平
Chen Xixi;Li Shuzhen;Li Ping(Reproductive Medical Center, Jiangmen Central Hospital, Jiangmen 529000, Chin)
出处
《国际医药卫生导报》
2017年第22期3495-3497,3508,共4页
International Medicine and Health Guidance News
关键词
体外受精-胚胎移植
来曲唑
卵巢储备低下
In vitro fertilization - embryo transfer
Letrozole
Poor ovarian reserve
