摘要
目的探讨类似于卵巢性索肿瘤的子宫肿瘤(UTROSCT)的临床及组织病理学特征、诊断与鉴别诊断。方法分析2例经HE和免疫组化En Vision两步法染色、会诊为UTROSCT的临床及病理学资料,并复习相关文献。结果镜下见肿瘤由上皮样细胞构成,呈梁状、条索状、巢状或管状排列,其间有簇状分布的泡沫样细胞;瘤细胞胞质呈嗜酸或泡沫样,核圆形或卵圆形,大小一致,核仁不明显,核分裂象少见;间质玻璃样变。免疫组化:瘤细胞AE1/AE3、vimentin、desmin、calretinin、WT-1、CD99、inhibin、CD10、ER和PR(+),EMA、Pax-8、CK7、melan A和caldesmon均为(-)。结论 UTROSCT是子宫罕见的具有卵巢性索肿瘤样形态特征的肿瘤,具有低度恶性潜能,多数肿瘤呈良性经过,少数可有复发和转移。临床及影像学不能明确诊断,最终确诊依赖于组织学形态特点及免疫组化。
Objective To describe the clinical pathological features,diagnosis and differential diagnosis of uterine tumors resembling ovarian sex cord tumors（ UTROSCT）. Methods The clinical and pathological data were retrospectively analyzed in 2 cases of UTROSCT in our hospital. Results Under the microscope,the tumor was composed of epithelioid cells in trabecular,cord,nests or tubular arrangement,with the distribution of the clusters of foam sample cells; Tumor cell cytoplasm was eosinophilic or foamy,with round or ovoid nucleus,uniform size,lack of nucleoli and rare mitosis;stromal hyalinization was noted. Immunohistochemical staining showed that the tumor cells expressed AE1/AE3,vimentin,desmin,calretinin,WT-1,CD99,inhibin,ER,PR and CD10,but not EMA,Pax-8,CK7,Melan A and caldesmon.Conclusion UTROSCT is a rare tumor with morphological characteristics of ovarian sex cord tumor and a low malignant potential; most of the tumors are benign,but a few can recur with metastasis. Clinical and radiographic changes cannot make the diagnosis and the final diagnosis depends on the histological features and immunohistochemical findings.
出处
《诊断病理学杂志》
2017年第9期651-654,共4页
Chinese Journal of Diagnostic Pathology
关键词
卵巢性索肿瘤
子宫肿瘤
免疫组化
诊断
鉴别诊断
Uterine tumors resembling ovarian sex cord tumor
Uterine tumor
Immunohistochemical
Diagnosis
Differential diagnosis
