摘要
目的探讨罕见的类似于卵巢性索肿瘤的子宫肿瘤(UTROSCT)的临床病理特征、免疫表型和鉴别诊断。方法分析1例UTROSCT的临床特点,并进行组织病理学和免疫组化检查。结果肿瘤组织界限不清,向周围平滑肌组织浸润性生长;瘤细胞呈上皮样,小梁、条索、巢状及假腺样排列伴坏死,有的呈网状、乳头状。瘤细胞胞质嗜酸或透亮,核圆形、卵圆形,可见小核仁,偶见核分裂象;间质玻璃样变、胆固醇裂隙形成伴钙化。免疫组化显示肿瘤细胞性索标记物calretinin、CD99、inhibin、CK、vimentin、CD10、ER和PR等(+),神经内分泌标记物Syn和CD56等(+)。结论 UTROSCT是子宫少见的具有卵巢性索肿瘤样形态特征的肿瘤,其生物学行为有待于进一步研究。
Objective To describe the clinical pathological features, immunohistochemistry features and differential diagnosis of uterine tumors resembling ovarian sex cord tumor rare （UTROSCT）. Methods The clinical findings, morphologic features and immunohistochemical markers in one cases of UTROSCT were studied. Results Tumor tissue was unclear, growing in to the surrounding smooth muscle invasively; The tumor cells were epithelioid, trabecular, cord, nests and pseudoglandular arrangements with necrosis; some reticular, papillary. Tumor cell cytoplasm was eosinophilic or clear, nucleus was round, ovoid, with small nucleoli, and occasional mitotic figure was also noted; stromal hyalinization, cholesterol cleft formation with calcification were found. Immunohistochemical staining showed that the tumor cells expressed sex-cord markers （calretinin, CD99 and inhibin）, CK, vimentin, CD10, ER and other neuroendocrine markers such as Syn and CD56. Conclusion Morphology and immunophenotype support that UTROSCT is a rare uterine tumor with sex cord tumor-like phenotype, and the biological behaviors need to be further studied.
出处
《诊断病理学杂志》
CSCD
北大核心
2014年第9期553-556,共4页
Chinese Journal of Diagnostic Pathology
关键词
类似于卵巢性索肿瘤的子宫肿瘤
性索样瘤
免疫组化
Uterine tumors resembling ovarian sex cord tumor
Sex-cord like tumor
Immunological phenotype
