摘要
虽然"肺主宣发肃降"理论已被中医普遍接受,但将传统理论与现代生物学相结合,用现代科学诠释其科学内涵一直存在着争议。对相关经典理论、方药以及所涉及的药效物质基础与生物学机制进行梳理,并提出了"肺为藏之长"的效应与功能可能取决于不同效应器官上所表达的肾上腺素能受体的亚型以及量的差异;苯乙胺类生物碱及其衍生物是其主要的药效物质基础,中医巧妙地选择了不同的天然药效分子实现了相关信号通路的调控,适应了临床治疗的不同需求;β-AR/c AMP/PKA信号通路是"肺主宣发"发挥效应的关键通路之一;"肺主治节"所体现的核心内容与肌球蛋白轻链的磷酸化水平的调控密切相关;方剂配伍能有效地增强肾上腺素能受体相关的多条信号通路之间的串扰,体现了中医针对复杂疾病采用多通路、多靶点综合治疗的优势。
Although the basic theory of ＂Xuanfa Sujiang＂ has been generally accepted by Chinese medicine practitioners, it is still controversial that traditional Chinese medicine（TCM） theory is combined with modern biology and interpreted by modern science. Based on relevant classical theories, prescriptions, pharmacological substance basis and biological mechanism, we put forward the following points in this paper： The effect and function of ＂Feiqi＂ governing organ movement depends on the difference about subtype or expression of adrenergic receptors on the post ganglionic fibers dominated autonomic effector. Coincidentally, TCM theory selected different types of natural effective molecules, such as phenylethylamine and its derivatived alkaloid, to achieve a good sympathetic regulation, and just meet the different needs of clinical treatment; The β-AR/c AMP/PKA signaling pathway is the core pathways for positive regulation; The concept of the ＂Zhijie＂ is closely related to the balance of myosin light chain phosphorylation and dephosphorylation levels; Prescription compatibility can effectively enhance the crosstalk between adrenergic receptor-related multiple signal pathways, and reflect the advantages of TCM for complex diseases treatment by multi-ingredients and multi-targets.
出处
《中草药》
CAS
CSCD
北大核心
2017年第19期3901-3909,共9页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(81373506,81430095,81374046)
关键词
肺主宣发
肺主治节
肾上腺素受体
药效物质基础
分子机制
dispersing function of Fei （Xuanfa）
Fei regulating visceral activities （Zhijie）
adrenergic receptor
effective substance basis
molecular mechanism
