摘要
目的:探讨康莱特联合奥施康定对于提高癌痛的止痛效果及患者生活质量的临床疗效,分析其临床应用价值。方法:选择2015年9月-2016年9月在本院就诊的晚期癌痛患者84例,根据随机原则将其均分为对照组和观察组,其中对照组采用单一的奥施康定口服止痛,而观察组采用奥施康定联合康莱特注射液治疗方案,采用癌症患者生命质量量表(The Quality of Life Questionnaire-Core 30,EORTC QLQ-C30)评分评估患者生活质量,并采用疼痛数字评分法(NRS)评估两组疼痛控制情况,同时对比治疗后不良反应发生率。结果:在EORTC QLQ-C30量表评分对比中,两组治疗后总评分较治疗前均有明显改善(P<0.05),其中治疗后对照组评分为(42.82±11.83)分,观察组为(50.91±12.76)分,两组比较差异有统计学意义(P<0.05)。症状领域7个项目中,观察组疼痛、睡眠困难,恶心呕吐、食欲的评分均低于对照组,差异均有统计学意义(P<0.05)。疼痛控制情况中,对照组疼痛缓解率为80.95%,而观察组高达97.62%,比较差异有统计学意义(P<0.05)。不良反应主要为便秘、恶心呕吐、头晕等,其中观察组加用康莱特后静脉炎发生率较对照组明显增多,恶心发生率较对照组明显下降,比较差异均有统计学意义(P<0.05)。结论:对于晚期癌痛患者,可以采用康莱特联合奥施康定治疗的方案,不仅治疗后疼痛缓解率高,同时患者的生活质量也有明显改善,相关不良反应减轻,安全性可靠,值得临床推广。
Objective：To explore the clinical curative effect of Kanglaite combined with Oxycontin to improve the quality of life of patients with cancer pain and analyze its clinical application value.Method：84 cases of patients with advanced cancer pain treated in our hospital from September 2015 to September 2016 were selected,according to the random principle they were divided into the control group and the observation group,the control group was treated with Oxycontin oral analgesic,and the observation group was treated with Oxycontin combined with Kanglaite Injection,evaluated the patients＇ quality of life using the Quality of Life Questionnaire-Core 30（EORTC QLQ-C30）,assessed the pain control using the digital pain score（NRS）,and after treatment,the incidence of adverse reactions of two groups were compared.Result：EORTC QLQ-C30 scores of two groups after treatment were significantly improved compared with before treatment（P0.05）,after treatment,the score of the control group was（42.82±11.83）,and the observation group was（50.91±12.76）,the difference was statistically significant（P0.05）,the score of pain,dyscoimesis,naupathia,appetite loss of the observation group were lower than those of the control group,the differences were statistically significant（P0.05）.The pain relief rate of the control group was 80.95%,and the observation group was 97.62%,the difference was statistically significant（P0.05）.The adverse reactions were constipation,nausea,vomiting,dizziness and so on,frequencies of phlebitiss of the observation group were higher than those of the control group（P0.05）,but the incidences of nausea were lower than those of the control group（P0.05）.Conclusion：For patients with advanced cancer treated with Oxycontin combined with Kanglaite,can improve pain relief rate and the quality of life of patients obviously,and relieve adverse reaction,safe and reliable,it is worthy of clinical application.
出处
《中国医学创新》
CAS
2017年第29期109-112,共4页
Medical Innovation of China
基金
湛江市科技计划项目(2015801177)
关键词
康莱特
奥施康定
癌痛
生活质量
Kanglaite
Oxycontin
Cancer pain
Quality of life
