摘要
目的探讨舌下含服多价昆虫抗原治疗儿童丘疹性荨麻疹的疗效及安全性,及其对患儿外周血IL-4和IL-17水平的影响。方法采用随机双盲、安慰剂平行对照研究方法,将入选的98例2~12岁丘疹性荨麻疹患儿分为治疗组(50例)和对照组(48例),分别给予舌下含服多价昆虫抗原或安慰剂治疗12周。比较两组患儿治疗前后有效率及治疗结束1年后复发率的差异,分析两组患儿治疗前后外周血IL-4和IL-17水平的变化。结果治疗组有效率(84.44%)明显高于对照组(52.17%),复发率低于对照组,差异均有统计学意义(P<0.05),不良反应均较轻微。结论舌下含服多价昆虫抗原治疗儿童丘疹性荨麻疹安全、有效。
Objective To investigate the clinical efficacy and safety of sublingual multivalence insect allergens in the treatment of children with papular urticarial,and its influence on IL-4 and IL-17 levels in peripheral serum.Methods A randomized double-blind, placebo parallel control trial was taken, 98 cases of 2-12 years old children with papular urticaria were choosen,divided into treatment group（n=50）and control group（n=48）, which were respectively given sublingual multivalence insect allergens or placebo for 12 weeks.The differences of the efficacy and recurrence rate before and after treatment between the two groups were compared, the changes of IL-4 and IL-17 in peripheral serum were analyzed.Results The efficiency of treatment group（84.44%）was significantly higher than the control group A（52.17%）,and the recurrence rate was lower than that of the control group,the difference were statistically significant（P〈0.05）,adverse reactions were mild.Conclusion Sublingual Multivalence Insect Allergens in the Treatment of Children with Papular Urticaria is safe and effective.
出处
《中国皮肤性病学杂志》
CSCD
北大核心
2017年第11期1278-1280,1284,共4页
The Chinese Journal of Dermatovenereology
基金
2014年贵州省卫生计生委科学技术基金项目
