摘要
目的分析乳腺导管原位癌微浸润(ductal carcinoma in situ with microinvasion,DCIS-Mi)的危险因素及其临床病理特点与局部复发或远处转移的相关性。方法收集郑州大学第一附属医院2008年4月至2012年8月期间接受手术且经病理确诊的所有乳腺导管原位癌及乳腺微浸润癌病例,对其临床病理资料进行统计分析,并对乳腺微小浸润癌患者进行随访,分析其临床病理特点与局部复发或转移的相关性。结果 DCIS患者中多发病灶的存在与肿瘤间质微浸润的发生有关(P=0.005<0.05),肿瘤最大直径<3.5 cm的DCIS-Mi患者生存率高于直径≥3.5 cm患者(χ2=11.88,P=0.003<0.05)。结论具有多发可疑病灶的DCIS伴或不伴可疑浸润的患者存在微浸润的可能性大。肿瘤最大直径<3.5 cm的患者可能有更高的生存率,但未发现其与DCIS-Mi局部复发或转移有关。
Objective To investigate the risk factors of ductal carcinoma in situ with microinvasion( DCIS-Mi).Methods All cases of DCIS or DCIS-Mi were retrieved from April of 2008 to August of 2012. Clinicopathologic parameters were analyzed for entire cohort. Multivariate analysis was used to identify risk factors of DCIS-Mi and the correlation between clinicopathologic characteristics and distant metastasis. Results 138 cases were evaluated in this period. The DCIS-Mi was almost always encountered in the setting of DCIS. The presence of multiple lesions was proven as a risk factor of DCIS-Mi( P =0. 005 < 0. 05). There was significant difference between two survival curves,and the survival rate of the group with tumor size less than 3. 5 cm was higher than that of the group with tumor size greater than or equal to 3. 5 cm( χ2= 11. 88,P = 0. 003 <0. 05). Conclusion Patients with multiple lump demonstrated high possibility of DCIS-Mi. The group with tumor size less than 3. 5 cm has higher survival rate.
出处
《河南医学研究》
CAS
2017年第6期976-979,共4页
Henan Medical Research
关键词
乳腺癌
导管原位癌
微浸润
breast cancer
ductal carcinoma in situ
microinvasion
