摘要
目的:探讨替米沙坦联合胺碘酮对高血压合并房颤患者的血压、左心房内径及房颤复发的影响。方法:选择2014年1月至2016年1月我院高血压合并房颤患者186例,随机均分为氨氯地平组(接受氨氯地平联合胺碘酮治疗)和替米沙坦组(接受替米沙坦联合胺碘酮治疗),疗程6周。观察比较两组治疗前后患者血压、左心房内径的变化情况及6个月内房颤复发的情况。结果:与治疗前比较,两组治疗后收缩压、舒张压均显著下降,左心房内径显著减小(P均<0.01);治疗后,与氨氯地平组比较,替米沙坦组患者的血压[(137±6)/(85±7)mm Hg比(122±5)/(77±8)mm Hg]、左心房内径[(38.7±2.3)mm比(35.3±3.4)mm]、6个月内房颤复发率(37.6%比22.6%)均显著降低(P均<0.01)。结论:对于高血压合并房颤患者,替米沙坦联合胺碘酮较氨氯地平联合胺碘酮更显著地降低血压和左心房内径,且明显降低房颤的复发率,值得推广。
Objective：To explore influence of telmisartan combined amiodarone on blood pressure,left atrial diame-ter and recurrence of atrial fibrillation （AF）in patients with hypertension complicated AF.Methods：A total of 186 patients with hypertension complicated AF treated in our hospital from Jan 2014 to Jan 2016 were selected.They were randomly and equally divided into amlodipine group （received amlodipine combined amiodarone）and telmisar-tan group （received telmisartan combined amiodarone）,the course of treatment was six weeks for both groups. Changes of blood pressure and left atrial diameter before and after treatment,and AF recurrence within six months were observed and compared between two groups.Results：Compared with before treatment,there were significant reductions in systolic blood pressure,diastolic blood pressure and left atrial diameter in both groups after treatment, P 〈0.01 all;compared with amlodipine group after treatment,there were significant reductions in blood pressure [（137±6）/ （85±7）mmHg vs.（122±5）/ （77±8）mmHg],left atrial diameter [（38.7±2.3）mm vs.（35.3 ±3.4）mm]and AF recurrence rate within six months （37.6% vs.22.6%）in telmisartan group,P 〈0.01 all. Conclusion：Compared with amlodipine combined amiodarone group,telmisartan combined amiodarone can more significantly reduce blood pressure and left atrial diameter,and significantly reduce recurrence rate of atrial fibrilla-tion in patients with hypertension complicated atrial fibrillation,which is worth extending.
出处
《心血管康复医学杂志》
CAS
2017年第5期526-529,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
高血压
心房颤动
胺碘酮
替米沙坦
Hypertension
Atrial fibrillation
Amiodarone
Telmisartan
