摘要
食管癌的具体发生机制尚未完全阐明,也缺乏有效的治疗措施,进展期食管癌5年生存率仅20%~30%。在食管癌前病变及早癌阶段进行治疗,可以明显改善患者预后,提高5年生存率。动物模型的建立加速了现代医学的科研进程,使我们对疾病,尤其是肿瘤性疾病的演变过程有了更深入的了解。近年来,食管癌的发病率有所增加,构建理想的动物模型有助于探索食管癌的具体发病机制,为食管癌的治疗提供理论依据。本文对常见的食管癌前病变及早癌建模方法做一综述。
The specific mechanisms of esophageal cancer are still unclear.Effective treatment strategies are lack for advanced esophageal cancer and the 5-year survival rate is only 20%-30%.Treatment for the precancerous or early stage of esophageal cancer can significantly improve the prognosis of patients and 5-year survival rate.Animal models accelerate the development of modern medicine which can help us have a better understanding of the pathogenesis and treatment strategies of diseases,especially diseases with lower incidence rate such as cancers.In recent years,the incidence rate of esophageal cancer has increased.Constructing an ideal animal model helps to explore the specific mechanisms of esophageal cancer and provide theoretical basis for the treatment of esophageal cancer.This paper summarizes the common methods of constructing esophageal precancerous lesions and early esophageal cancer in animal models.
出处
《中华胃肠内镜电子杂志》
2017年第3期130-135,共6页
Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition)
关键词
食管癌前病变
早癌
动物模型
Esophageal precancerous lesions
Early esophageal cancer
Animal models
