摘要
目的探讨叶酸联合阿仑磷酸钠及钙剂治疗老年男性骨质疏松的效果。方法选择2014年6月至2016年12月在常德市第一人民医院门诊和住院的老年男性骨质疏松患者100例作为研究对象,将其随机分为观察组和对照组,各50例。两组患者均予以综合治疗。对照组服用阿仑膦酸钠,每周70 mg,同时服用钙剂(钙尔奇-D,每片含钙600 mg及维生素D3125 U),每天1片;观察组在对照组治疗基础上服叶酸片,每天0.8 mg,两组连续治疗12个月。观察两组患者治疗前后的骨密度变化,并对骨痛缓解率进行比较。结果观察组L2~4治疗前后骨密度分别为(0.83±0.10)、(1.04±0.08)g/cm2,二者比较,差异有统计学意义(P<0.05)。对照组L2~4治疗前后骨密度分别为(0.81±0.11)、(0.93±0.10)g/cm2,二者比较,差异有统计学意义(P<0.05)。观察组治疗后的骨密度较对照组增加,差异有统计学意义(P<0.05)。观察组骨痛缓解的总有效率为96.0%(48/50),而对照组为94.0%(47/50),二者比较,差异无统计学意义(P>0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论叶酸联合阿仑膦酸钠及钙剂治疗老年男性骨质疏松效果好,安全性较高,临床值得推广。
Objective To discuss the therapeutic effect on folic acid combination with calcium tablet and caltrate-D in the treatment of elderly male patients with osteoporosis. Methods A total of 100 erderly male patients with osteoporosis in the outpatient and hospitalization of the first people′s hospital of Changde from June 2014 to December 2016 were divided into observation group（50 cases）and control group（50 cases）randomly. All patients were given comprehensive treatment. Control group was given calcium tablet one piece oral（caltrate-D,there were 600 mg calcium in every tablet with 125 U vitamin D3）and alendronate sodium 70 mg a week,observation group was given calcium tablet one piece and alendronate sodium 70 mg a week plus folic acid0.8 mg everyday,which was treated continuously for 12 months. Changes in bone mineral density of two groups were observed be-fore and after treatment,and the bone pain remission rate and adverse effects rate were compared. Results Bone mineral density in L2-4of observation group were（0.83±0.10）,（1.04±0.08）g/cm2 before and after treatment respectively,there was significant difference（P〈0.05）. Bone mineral density in L2-4of control group were（0.81±0.11）,（0.93±0.10）g/cm2 before and after treatment respectively,there was significant difference（P〈0.05）. Bone mineral density of observation group was higher than that of control group after treatment,there was significant difference（P〈0.05）. Bone pain remission rate of observation group was 96.0%（48/50）,and that of control group was 94.0%（47/50）,there was no significant difference（P〉0.05）. There was no significant difference in adverse reactions between the two groups（P〉0.05）. Conclusion The therapeutic effect of calcium and alendronate sodium plus folic acid in the treatment of elderly male patients with osteoporosis is preferable with excellent security,so it is worth of promotation in clinic.
出处
《现代医药卫生》
2017年第20期3104-3105,3108,共3页
Journal of Modern Medicine & Health
