摘要
目的:本文研究了阿苯达唑(ABZ)在石墨烯与离子液体(N-丁基吡啶六氟磷酸盐)复合修饰碳糊电极上的电催化氧化及电化学性质,建立了阿苯达唑的电化学定量检测方法。方法:循环伏安法(CV法),计时库仑法(CC法)、计时电流法(CA),方波伏安法(SWV)。结果:ABZ在GR-[Bupy]PF6/CPE上具有良好的电化学行为,而且ABZ在此电极上的电化学氧化是一受扩散控制的不可逆电极反应过程,并用SWV法测的ABZ氧化峰电流(Ip)与其浓度在9.0×10^(-7)~2.0×10^(-4)mol·L^(-1)范围内呈良好的线性关系,线性回归方程为Ip(μA)=4.804+198.522c(10^(-3)mol·L^(-1)),R=0.9987,检测限(S/N=3)为1.4×10-8 mol·L-1。结论:GR-[Bupy]PF6/CPE对ABZ的电化学氧化具有良好的催化作用,该方法可用于对市售的ABZ片剂中ABZ含量进行电化学定量测定,且检测限低,检测范围宽。
Objective： Electrocatalytic oxidation and its electrochemical properties of Albendazole （ABZ） were investigated at carbon paste electrode （CPE） which modified by graphene （GR） and [BupyJPF6. Also an electrochemical quantitative determination had been established. Methods： Cyclic voltammetry （CV）, chronocoulometry （CC）, cbronoamperometry （CA）, square wave voltammetric （SWV）. Results： The experiment results indicated that ABZ electrochemical behaviors exhibits a sensitive irreversible electrochemical oxidation progress at GR-[Bupy]PFJCPE, The oxidation peak current of ABZ versus its concentration had a good linear relationship in the concentration range of 9.0× 10 -7-2.0× 10 -4 mol·L-1 and the detection limit （S/N=3） was 1.4× 10 -8 mol·L-1 by square wave voltammetric （SWV） method. The equation of linear regression was Ip（μtA）=4.804＋198.522c（10 -3 mol·L-1）, R=0.9987. Conclusion： The experimental result indicated that GR-[Bupy]PFJCPE could catalyze the oxidation of ABZ well with a wide detection range and low detection limit, and the proposed method have been applied in electrochemical quantitative determination of ABZ content in commercial tablet samples.
作者
田碧桃
高作宁
屈旭斌
Tian Bitao Gao Zuoning Qu Xubin(Technology Center of Ningxia Entry-exit Inspection and Quarantine Bureau, Yinchuan 750021 College of Chemistry and Chemical Engineering, Ningxia University, Yinchuan 750021 East＆West Analytical Instrument Ltd, Beijing 100044, China)
出处
《广东化工》
CAS
2017年第20期79-81,共3页
Guangdong Chemical Industry
关键词
阿苯达唑
石墨烯
碳糊电极
电分析方法
albendazole
graphene
carbon paste electrode
electrochemical determination
