摘要
目的评价产前补充肌肉肌醇预防肥胖孕妇妊娠期糖尿病(GDM)的临床疗效。方法选择125例肥胖孕妇为研究对象,随机分为肌醇治疗组(62例)和对照组(63例)。肌醇治疗组从妊娠早期至分娩给予肌肉肌醇2 g以及叶酸200μg的混合治疗,每天二次;对照组给予叶酸200μg治疗,每天二次。观察两组的GDM发生率以及从妊娠早期至妊娠24~30周口服葡萄糖耐量试验(OGTT)时胰岛素抵抗指数的变化。结果肌醇治疗组GDM的发生率明显低于对照组,差异有统计学意义(χ~2=6.57,P<0.05)。肌醇治疗组胰岛素抵抗指数变化明显低于对照组,差异有统计学意义(t=3.33,P<0.05)。结论肥胖孕妇妊娠早期补充肌肉肌醇可以通过减少胰岛素抵抗而减少GDM的发生率,有助于临床上对GDM的预防及干预。
Objective To evaluate the clinical efficacy of antenatal inositol supplementation on preventing gestational diabetes mellitus in obese pregnant women. Methods A total of 125 cases of obese pregnant women were included and randomized into the inositol treatment groups（62 cases） and the control groups（63 cases）. Patients in the inositol treatment group were received regimens consisting of 2 g myo-inositol and 200μg folic acid,twice a day.And the control group was received 200 μg folic acid twice a day only. The incidences of GDM were observed and the changes of the insulin resistance indexes between two groups were compared when taken the oral glucose tolerance tests（OGTT）at the first trimester and 24 to 30 weeks of gestation. Results The incidence of GDM in the inositol treatment group was significantly lower than that of the control group（χ2=6.57,P 〈0.05）. The insulin resistance index in inositol treatment group showed a significantly reduction compared with the control group（t=3.33,P 〈0.05）. Conclusion Myo-inositol supplementation in the early trimester of obese pregnancy women is significantly effective in reducing the incidence of GDM through a reduction of insulin resistance,which contributing to the clinical prevention and intervention of GDM.
出处
《全科医学临床与教育》
2017年第5期531-533,共3页
Clinical Education of General Practice
关键词
肌醇
肥胖
妊娠期糖尿病
孕妇
myo-inositol
obese
gestational diabetes mellitus
pregnancy
