摘要
目的观察比索洛尔联合螺内酯治疗老年慢性心力衰竭的临床效果。方法 106例老年慢性心力衰竭患者随机分为对照组和观察组。对照组按照慢性心力衰竭常规治疗方案进行干预,观察组在此基础上采用比索洛尔联合螺内酯治疗。对比两组的疗效,观察患者治疗前后舒张末期室间隔厚度(IVST)、舒张末期左心室内径(LVEDD)、左心室射血分数(LVEF)以及肿瘤坏死因子(TNF-α)、白细胞介素6(IL-6)、NT-proBNP浓度、6 min步行试验的改变。结果观察组的临床疗效优于对照组(P<0.01)。治疗后,观察组的LVEDV、LVESV水平均低于对照组;CI、SV、LVEF、6 min步行距离则高于对照组;治疗后两组患者的TNF-α、IL-6、血清NT-proBNP均低于治疗前,且以观察组更为显著(P<0.05或0.01)。结论采用比索洛尔联合螺内酯治疗老年慢性心力衰竭能够有效提高患者的临床疗效,改善患者的心室重构和心功能。
Objective To investigate the clinical effect of bisoprolol combined with spironolactone in the treatment of elderly patients with chronic heart failure. Methods 106 elderly patients with chronic heart failure patients admitted to the hospital were randomly divided into Control Group and Observation Group. Control Group was intervened with conventional therapeutic regimen while Observation Group was treated with bisoprolol combined with spironolactone based on the conventional treatment. The efficacy of the two groups was compared and the changes in IVST, LVEDD, LVEF, TNF-α, IL-6, NT-proBNP concentration and 6 min walking test of the patients before and after treatment were observed. Results the clinical curative effect of Observation Group was significantly superior to that of Control Group （P〈0.01）, and the difference was statistically significant （P〈0.01）. After treatment, the in Observation Group had the LVEDV and LVESV level lower than Control Group, and the CI, SV, LVEF and 6 minutes walking distance higher than Control Group. After treatment, both groups had the TNF-, IL-6, serum NT-proBNP significantly lower than before treatment, and Observation Group showed a more significant difference. Conclusion The spironolactone combined with bisoprolol for the treatment of the elderly patients with chronic heart failure can effectively improve the clinical curative effect and improve the ventricular remodeling and heart function of the patients.
作者
陈允祥
陈宋璋
黄炯泽
CHEN Yun-xiang CHEN Song-zhang HUANG Jiong-ze(Vasculoeardiology Department of the Puning People＇s Hospital, Puning 515300, China)
出处
《广东医科大学学报》
2017年第2期119-121,共3页
Journal of Guangdong Medical University
关键词
慢性心力衰竭
螺内酯
比索洛尔
临床疗效
chronic heart failure
spironolactone
bisoprolol
clinical efficacy
