摘要
目的探究影响复发性卵巢癌妇女无瘤生存状况的危险因素。方法选取2013年5月～2015年5月于本院确诊为复发性卵巢癌并进行治疗的复发性卵巢癌患者为研究对象，共计94例。回顾性分析患者病历，并对患者进行为期6个月的随访，收集患者治疗后的预后因素，统计患者年龄、病理类型、病理分级等相关指标进行分析，得出影响复发性卵巢癌患者的无瘤生存期的危险因素。结果高分化级、中分化级、低分化级患者中位无瘤生存期分别为17．8个月、11．7个月、6．9个月，高分化级患者中位无瘤生存期明显长于中、低分化级，差异具有统计学意义（P〈0．05）。首次术后残余病灶直径〈1cm、直径≥1cm患者的无瘤生存期分别为16．6个月、4．3个月，直径〈1cm患者中位无瘤生存期明显长于直径≥1cm患者，差异具有统计学意义（P〈0．05）。浆液性癌、黏液性癌、子宫内膜样癌、未分类腺癌、颗粒细胞癌的无瘤生存期分别为6．7个月、33．5个月、15．6个月、4．3个月、137．5个月，颗粒细胞癌患者无瘤生存期明显长于其他类型，差异具有统计学意义（P〈0．05）。临床Ⅰ／Ⅱ期、Ⅲ／Ⅳ期患者无瘤生存时间分别为32．0个月、7．5个月，临床Ⅰ／Ⅱ期患者无瘤生存时间明显长于Ⅲ／Ⅳ期，差异具有统计学意义（P〈0．05）。化疗疗程〈6个患者、26个患者无瘤生存期分别为5．0个月、12．5个月，化疗疗程〉16个患者无瘤生存期明显长于化疗疗程〈6个患者，差异具有统计学意义（P〈0．05）。首次术后残留病灶直径、临床分期多因素分析结果P值分别为0．006、0．012，是影响患者无瘤生存期的独立危险因素。结论首次术后残留病灶直径、临床分期是影响复发性卵巢癌妇女无瘤生存期的独立危险因素，因此医护人员在手术过程中应当注意切除肿瘤的彻底性，并加强�
Objective To explore the risk factors of tumor - free survival in the women with recurrent ovarian cancer. Methods 94 patients with recurrent ovarian cancer from January in 2008 to January in 2015 in our hospital were selected. The prognostic factors of the patients were collected, and the patients＇ age, pathologic type and pathologic grade were analyzed. The risk factors during the period of tumor - free survival in the patients with recurrent ovarian cancer were collected and analyzed. Results The median tumor - free survival of the well - differentiated, moderately differentiated and poorly differentiated patients was 17.8 months, 11.7 months and 6. 9 months respectively. The median survival time in the well - differentiated patients was significantly longer than that in the moderately and poorly differentiated ones. There were statistically significant difference （P 〈 0. 05 ）. The median survival time in the patients with diameter 〈 lcm and diameter ≥1cm of the residual lesion after the first operation was 16. 6 months and 4. 3 months respectively. The median survival time in the patients with diameter 〈 1 cm of the residual lesion was significantly longer than that in the patients with diameter ≥1 cm of the residual lesion after the first operation. There were statistically significant difference （P 〈 0. 05 ）. The tumor - free survival time of serious carcinoma, mucinous carcinoma, endometrioid carcinoma, unclassified adenocarcinoma and granulosa cell carcinoma was 6. 7 months, 33.5 months, 15.6 months, 4. 3 months and 137.5 months respectively. The tumor - free survival time of granulosa cell carcinoma was significantly longer than that of other types of the tumor. There were sta- tistically significant difference （P 〈0. 05）. The survival time of the patients with stage Ⅰ / Ⅱ and Ⅲ/Ⅳ was 32. 0 months and 7.5 months respectively. The survival time of the patients with stage Ⅰ/ Ⅱ was longer than that of the patients with Ⅲ/Ⅳ stage. There were statistically significa
作者
高丽梅
徐进志
李鑫
王晓慧
Gao Limei Xu Jinzhi Li Xin Wang Xiaohui(Department of Gynaecology and Obstetrics, the People＇ s Hospital of Tangshan, Tangshan 063001, China The Fourth Hospital, Haerbin Medical University, Haerbin 150000, China)
出处
《国际老年医学杂志》
2017年第5期215-217,226,共4页
International Journal of Geriatrics
基金
黑龙江省自然科学基金（D200903）
关键词
复发性
卵巢癌
无瘤生存期
Recurrent
Ovarian cancer
Tumor - free survival
