摘要
以磁性四氧化三铁(Fe_3O_4)纳米粒子和可降解聚合物聚乳酸-羟基乙酸共聚物为原料,采用乳化-溶剂挥发法制备获得磁性聚合物微球。通过傅里叶红外光谱、热失重曲线、透射电子显微镜、振动样品磁强计对所制备的磁性聚合物微球的各项性能进行表征,并利用高频磁感应设备测定磁性聚合物微球的磁感应加热性能。结果表明,所制备的两种磁性聚合物微球中Fe_3O_4纳米粒子的含量分别为10.1%和18.8%,其比饱和磁化强度分别为2.3 emu/g和6.8 emu/g;在高频磁场作用下,8 min内升温分别可达到9℃和16.5℃,完全满足肿瘤磁热疗的升温需求,在肿瘤磁热疗及热化疗结合治疗中有着很好的应用潜力。
In this paper, magnetic polymer microspheres were prepared via emulsion-solvent evaporation method, with magnetic Fe3O4 nanoparticles and biodegradable polymer poly（lactic-co-glycolic acid）. The structures and properties of microspheres were characterized with Fourier transform infrared spectroscopy, thermogravimetric analysis, transmission electron microscopy and vibrating sample magnetometer, and the electromagnetic induction heating property was also investigated. The obtained two magnetic polymer microspheres with Fe3O4 content of 10.1% and 18.8% exhibited saturation magnetization values of 2.3 emu/g and 6.8 emu/g, and temperature increased 9℃ and 16.5℃ under the electromagnetic induction. Results suggest that the obtained magnetic polymer microspheres meet the heating requirement of hyperthermia and have potential applications in magnetic hyperthermia or thermochemotherapy of cancer.
作者
李鹏辉
江敏
李炜澔
喻学锋
LI Penghui JIANG Min LI Weihao YU Xuefeng(Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China Department of Radiotherapy Oncology, Shenzhen People＇s Hospital, Shenzhen 518020, China)
出处
《集成技术》
2017年第5期1-7,共7页
Journal of Integration Technology
基金
国家自然科学基金项目(31500773)
深圳市基础研究自由探索项目(JCYJ20150401150223643)
关键词
乳化-溶剂挥发
磁性纳米粒子
聚合物微球
磁致热疗
emulsion-solvent evaporation
magnetic nanoparticles
polymer microspheres
magnetic hyperthermia
