摘要
氢气是一种新型、简单、安全的选择性抗氧化剂。但氢气的水溶性低、难以实时追踪和定点可控释放限制了其在生物医学上的应用。微泡具有造影、载气及定点可控释放的特性。文章将氢气与全氟丙烷通过一定比例混合制备了一种新型的载氢气微泡。体外、体内超声成像实验发现载氢气微泡在磷酸盐缓冲液以及在大鼠左心室和肝脏中均有很好的超声成像性能。该研究为进一步利用氢气微泡来实现超声定点释放和治疗奠定了实验基础。
Hydrogen gas（H_2） is a novel,simple and safe antioxidant.However,its poor solubility in water,the difficulties to track by imaging and to be released in a controllable manner limit its bio-medicine application.Microbubbles（MBs） are ideal ultrasound contrast agents and can be used as the ultrasound-activated drug carriers.In this work,hydrogen-loaded microbubbles（H_2-MBs） were prepared and their performance in ultrasound imaging in vitro and in vivo were examined.Experiment results showed that H_2-MBs have excellent ultrasound imaging capability both in phosphate buffered saline and in the rat left ventricular and liver.The study provided a novel H_2 formulation and laid the foundation for further H_2 therapy application.
出处
《集成技术》
2016年第4期37-43,共7页
Journal of Integration Technology
基金
国家自然科学基金(81571701
81371563)
深圳市科技计划(JCYJ20150521144321010
JCYJ20150331091304763)
关键词
氢气
微泡
超声成像
hydrogen
microbubbles
ultrasound imaging
