摘要
目的:探讨清胰汤辅助治疗急性重症胰腺炎的疗效。方法:选取2013年6月至2016年8月收治的急性重症胰腺炎患者58例,回顾治疗方案并分为接受常规西医治疗的对照组30例、接受清胰汤联合西医治疗的观察组28例。比较2组患者的治疗前后临床症状评分,血清炎性递质、肝肾功能指标水平的差异。结果:治疗前,2组患者的临床症状评分,血清炎性递质、肝功能指标、肾功能指标水平差异无统计学意义(P>0.05)。治疗后,观察组患者的腹痛、痞满燥实、恶心呕吐、口干口渴评分值低于对照组患者,血清中炎性递质C反应蛋白(CRP)、降钙素原(PCT)、单核细胞趋化蛋白-1(MCP-1)、人高迁移率族蛋白(HMGB-1)的水平低于对照组患者,肝功能指标天门冬氨酸转氨酶(AST)、谷丙转氨酶(ALT)、总胆红素(TBIL)的水平低于对照组患者,肾功能指标血肌酐(Scr)、尿素氮(BUN)的水平低于对照组患者。结论:清胰汤辅助治疗可显著减轻急性重症胰腺炎患者的临床症状,降低全身炎性反应、保护肝肾功能。
Objective： To study the curative effect of severe acute pancreatitis supplemented with Qingyi Decoction and its influence on systemic inflammatory response syndrome and key organs’ function. Methods： A total of 58 severe acute pancreatitis patients in our hospital during June 2013 to August 2016 were included in our study,and they were divided into control group（ 30 cases）,which received conventional western medicine treatment,and observation group（ 28 cases） which was treated Qingyi Decoction combined with western medicine therapy. The clinical symptom score,serum inflammatory mediators,liver and kidney function indexes in two groups were compared before and after treatment. Results： Before treatment,there were no significant differences between two groups in clinical symptom score,serum inflammatory mediators,liver function and renal function indexes（ P 〉 0. 05）.After treatment,the symptoms of abdominal pain,fullness,nausea and vomiting,dry mouth and dry thirst scores in observation group were lower than those in control group,serum contents of inflammatory mediators such as PCT,MCP-1,CRP,HMGB-1 were lower than those in control group,liver function indexes such as AST,ALT,TBIL were lower than those in control group,renal function indexes such as Scr,BUN were lower than those in control group. Conclusion： Qingyi Decoction therapy can significantly reduce the clinical symptoms of patients with severe acute pancreatitis,decrease systemic inflammatory response,and protect liver and kidney function.
作者
彭卓
万林
张瑞
樊媛
孙江利
裴红红
Peng Zhuo Wan Lin Zhang Rui Fan Yuan Sun Jingli Pei Honghong(Emergency Department, Xi ＇an Jiaotong University the Second Affiliated Hospital, Xi＇an 710004, China)
出处
《世界中医药》
CAS
2017年第9期2058-2061,共4页
World Chinese Medicine
基金
陕西省科技计划项目(2014K12-18)
关键词
急性重症胰腺炎
清胰汤
全身炎性反应
肝功能
肾功能
Severe acute pancreatitis
Qingyi Decoction
Systemic inflammatory response syndrome
Liver function
Renal function
