摘要
【目的】探究并分析乌司他丁联合苯乙哌啶对急性胰腺炎患者胃肠功能及可溶性E钙黏素(soluble E cadherin,sE-cad)、外周血单核细胞人白细胞DR抗原(peripheral blood mononuclear cells,human leukocyte DR antigen,mHLA-DR)表达的影响。【方法】选取2014年1月至2016年1月收治的100例急性胰腺炎患者,按照随机数字表法将其分为观察组和对照组,每组50例。对照组患者采用常规治疗,观察组患者在对照组基础上给予乌司他丁联合苯乙哌啶治疗,观察并记录下两组患者治疗前后胃肠功能(胃动素、胃泌素、呕吐消失、腹胀缓解和肛门排气排便)以及s E-CAD、mHLA-DR水平。【结果】经重复方差分析,两组患者sE-cad比较,差异具有统计学意义(P<0.05)。随着治疗的进行,两组患者sE-cad水平均有所下降,但观察组患者下降程度明显大于对照组(P<0.05)。两组患者mHLA-DR比较差异明显(P<0.05)。随着治疗的进行,两组患者mHLA-DR水平均有所上升,但观察组患者上升程度明显大于对照组(P<0.05)。观察组患者胃动素水平明显高于对照组(P<0.05),而胃泌素水平则明显低于对照组(P<0.05)。观察组患者呕吐消失、腹胀缓解以及肛门排气排便人数均明显多于对照组(P<0.05)。【结论】乌司他丁联合苯乙哌啶有效促进急性胰腺炎患者胃肠功能恢复,并改善患者s E-CAD以及mHLA-DR水平,值得临床广泛推广。
【Objective】To explore and analyze the effects of ulinastatin combined with diphenoxylate on the gastrointestinal function and expression of sE-CAD and mHLA-DR in patients with acute pancreatitis.【Methods】] A total of 100 patients with acute pancreatitis were selected from January 2014 to January 2016 and divided into observation group and control group according to a table of random numbers（n=50）.Patients in the control group were treated conventionally,while patients in the observation group were given ulinastatin combined with diphenoxylate based on the treatment for the control group.The gastrointestinal functions（motilin,gastrin,vomiting relief,abdominal distension relief and anal exhaust defecation） and expression levels of sE-CAD and mHLA-DR in both groups were observed and recorded before and after the treatment.【Results】Based on repeated analysis of variance,the levels of sECAD were significantly different between the two groups（P〈0.05）.With the treatment,the levels of sE-CAD decreased in both group,but the decline degree in the observation group was significantly higher than that in the control group（P〈0.05）.The levels of mHLA-DR between the two groups was significantly different（P〈0.05）.With the treatment,the levels of mHLA-DR in both groups increased,but the rising degree in the observation group was significantly higher than that in the control group（P〈0.05）.The level of motilin in the observation group was significantly higher than that in the control group（P〈0.05）,but the level of gastrin was significantly lower than that in the control group（P〈0.05）.Patients with vomiting relief,abdominal distension relief and anal exhaust defecation in the observation group were significantly more than those in the control group（P〈0.05）.【Conclusion】Ulinastatin combined with diphenoxylate can effectively promote gastrointestinal function recovery in patients with acute pancreatitis, and improve the levels of sE-CAD and mHLA-DR. It is worthy of wide c
作者
杨晓虎
徐玮
YANG Xiao-hu XU Wei(Xinjiang Training Base Medical Team, Command Headquarters of PAP, Urumqi 830000, Chin)
出处
《武警后勤学院学报（医学版）》
CAS
2017年第7期569-572,共4页
Journal of Logistics University of PAP（Medical Sciences）
关键词
乌司他丁联合苯乙哌啶
急性胰腺炎
胃肠功能
免疫因子
Ulinastatin combined with diphenoxylate
Acute pancreatitis
Gastrointestinal function
Immune factors
