摘要
目的探讨乌司他丁联合血必净对重症急性胰腺炎患者血清白细胞介素8（IL-8）和γ干扰素（IFN-γ）的影响。方法将70例重症急性胰腺炎患者应用随机数字表分为对照组和研究组，每组35例。对照组在常规治疗基础上给予乌司他丁治疗，研究组给予乌司他丁联合血必净治疗。疗程均为7d。比较两组患者腹胀缓解时间、腹痛缓解时间、血清淀粉酶（sAMY）恢复正常时间、白细胞计数（WBC）恢复正常时间、治疗前及治疗第3天和第7天血清IL-8和IFN-γ的变化。结果研究组与对照组腹胀缓解时间[（4．1±1．5）d与（6．2±2．4）d，t=5．468]、腹痛缓解时间[（4．2±1．9）d与（6．5±2．2）d，t=5．747]、sAMY恢复正常时间[（5．2±1．4）d与（6．8±2．5）d，t=4．354]及WBC恢复正常时间[（6．5±1．9）d与（8．9±2．5）d，t=4．647]比较，均明显优于对照组，差异均有统计学意义（P均〈0．05）。治疗3d和7d后，两组血清IL-8和IFN-γ较治疗前均明显下降，且研究组下降更为明显，差异均有统计学意义（P均〈0．05）。结论乌司他丁联合血必净可以明显降低重症急性胰腺炎患者血清IL-8和IFN-γ水平，减轻患者临床症状。
Objective To investigate the influence of ulinastatin combined with Xue Bi Jing injection therapy on serum interleukin interleukin-8 （ IL）-8 and γ-interferon （γ-IFN） of patients with severe acute pancreatitis （SAP）. Methods Seventy patients with SAP were randomly divided into the control group （n = 35） and research group（ n= 35）. Patients in the control group were given ulinastatin on the foundation of traditional treatment,and in research group were given Xue Bi Jing injection on the foundation of treatment of the control group. The rehef time of abdominal distension and abdominal pain, time of serum amylase （sAMY） and white blood cell count（WBC） returned to normal were recorded. The IL-8 and γ-IFN of before and after treatment of the two groups were measured. Results The relief time of abdominal distension, abdominal pain, times of serum amylase,WBC returned to normal in treatment group were （ 4. 1 ± 1.5） d, （ 4. 2± 1.9） d, （ 5.2± 1.4） d, （ 6. 5 ± 1.9） d respectively, significantly shorter than the control group （ （ 6. 2±2.4） d, （ 6. 5± 2. 2） d, （ 6. 8±2. 5） d, （8.9±2. 5） d;t=5. 468,5. 747,4. 354,4. 647;P〈0. 05）. The IL-8 and IFN-γ at the 3rd day and 7th day after treatment of the two groups decreased obviously, and those in the observation group were significantly lower than the control group （P 〈 0. 05 ）. Conclusion Ulinastatin combined with Xue Bi Jing injection therapy can conspicuously reduce the IL-8 and γ-IFN levels in patients with severe acute pancreatitis and alleviate the clinical symptom.
出处
《中国综合临床》
2015年第5期443-445,共3页
Clinical Medicine of China
