摘要
目的:探讨6~18岁高功能孤独症患者的灰质体积异常脑区以及异常脑区发育特点。方法:纳入19例6~18岁符合美国精神障碍诊断与统计手册第4版孤独症诊断标准且总智商≥70的高功能孤独症患者,以及年龄、总智商、性别组间匹配的16例正常对照,以磁共振成像检查收集被试的脑影像学资料,采用基于体素的形态学测量方法计算两组被试大脑各区域的灰质体积,在统计学参数图(SPM)软件SPM8中进行双样本t检验得出差异脑区,对结果进行错误率(FDR)多重比较校正(P<0.05)。采用偏相关分析两组被试差异脑区灰质体积与年龄的相关性。结果:高功能孤独症组的右侧额下回眶额部灰质体积小于正常对照组(FDR校正,P<0.05)。正常对照组右侧额下回眶额部灰质体积与年龄呈负相关(r=-0.592,P<0.05),高功能孤独症患者右侧额下回眶额部灰质体积与年龄呈负相关(r=-0.696,P<0.01)。结论:与正常人相比,6~18岁高功能孤独症患者右侧额下回眶额部发育异常,此脑区可能参与孤独症的病理机制。
Objective： To explore the abnormal gray matter volume regions of brain and the developmental characteristic of abnormal regions in patients with high functioning autism during 6 - 18 years old. Methods： The study enrolled 19 patients and 16 age, sex and intelligent quotient matched normal controls. The patients met the diagnostic criteria of autism in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Faition. The full scale intelligence quotients of patients and normal controls were greater than＇ or equal to 70. The magnetic resonance imaging （MRI） was used to collected brain images. Voxel-based morphometry was used to process the MRI images and two sample t-test in Statistical Parametric Mapping-8 （SPM8） was used to analyze differences between the two groups in gray matter volume of brain. The results were controlled with false discovery rate （FDR） multiple compar- ison correction （P 〈 0.05）. Partial correlative analysis was performed to examine correlation between gray matter volume of abnormal brain region and age in two groups. Results： Compared with normal controls, patients with high functioning autism during 6 - 18 years old exhibited smaller gray matter volume at right inferior orbital frontal （P 〈 0. 05, FDR corrected）. In patients with high functioning autism, the volume of right inferior orbital frontal was negatively correlated with age（r = 0. 70, P 〈 0. 01）. The negative correlation between the volume of right inferior orbital frontal and age was also found in normal controls（ r = -0. 59, P 〈 0. 05）. Conclusion： It suggests that right inferior orbital frontal of brain is abnormal in patients with high functioning autism during 6 - 18 years old. The right inferior orbital frontal may be significant for pathological mechanism of autism.
出处
《中国心理卫生杂志》
CSSCI
CSCD
北大核心
2017年第10期775-780,共6页
Chinese Mental Health Journal
基金
国家自然科学基金(81271508)
国家自然科学基金(81571339)
北京市自然科学基金(7164314)
关键词
高功能孤独症
脑灰质
磁共振成像
右侧额下回眶额部
high functioning autism, gray matter, magnetic resonance imaging, right inferior orbital frontal
