期刊文献+

西洋参冻干粉亚急性毒性研究 被引量:1

Subacute toxicity of American ginseng lyophilized powder
原文传递
导出
摘要 目的探讨西洋参冻干粉对SD大鼠的亚急性毒性。方法将80只SPF级大鼠随机分为高、中、低西洋参组(3.00、1.50和0.75 g/kg)和对照组,对照组喂养基础饲料,西洋参组喂饲参有相应比例西洋参的基础饲料,连续喂养30 d;观察大鼠摄食量、体重增重、主要脏器的脏体比、食物利用率变化,采用血细胞分析仪、生化分析仪检测大鼠血常规、血清生化学指标,主要脏器进行病理学观察。结果对照组及各剂量西洋参组大鼠生长发育状况良好、无死亡,精神状态与活动状况未见异常;与对照组比较,各剂量西洋参组大鼠摄食量、体重增长、食物利用率、脏体比无明显变化,血常规、血液生化等指标无明显差异;对照组及高剂量西洋参组大鼠肝、肾、脾、睾丸、卵巢等主要脏器未见明显病理改变。结论西洋参冻干粉对大鼠无明显亚急性毒性。 Objective To investigate the subacute toxicity of American ginseng lyophilized powder to Sprague-Dawley (SD) rats.Methods Eighty specific pathogen free (SPF) rats were randomly divided into three groups:high,moderate and low dose American ginseng groups (3.00,1.50 and 0.75 g/kg) and a control group.The control group were fed with basal feed and the American ginseng groups fed with the feed mixed by various contents of American ginseng for 30 days.Food intake,weight gain,viscera ratio of the main organs,and the change of food utilization rate of the rats were observed.The rats' routine blood indexes and serum biochemical indicators were detected using blood cell analyzer and biochemical analyzer.Pathological examinations were conducted for main organs of the rats.Results There were no abnormalities in the growth and development of the rats of control group and American ginseng groups;no death and abnormal statuses of mental and physical activity were observed in all the rats.Compared with those of the control group,the rats of American ginseng groups showed no significant differences in body weight gain,food utilization,and functions of main organs.There were no obvious pathological changes in the liver,kidney,spleen,testis or ovary of in the rats of the control group and the high dose American ginseng group.Conclusion American ginseng lyophilized powder is of no significant subacute toxicity to rats.
出处 《中国公共卫生》 CAS CSCD 北大核心 2017年第9期1363-1366,共4页 Chinese Journal of Public Health
基金 基金项目:初级农产品生产质量安全监测及预警技术研究(2008215002)
关键词 西洋参 亚急性毒性 血清生化学 American ginseng subacute toxicity serum biochemistry
  • 相关文献

参考文献9

二级参考文献175

共引文献188

同被引文献10

引证文献1

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部