摘要
目的:观察服用非典型抗精神病药物的患者出现便秘的发生率及影响因素。方法:对530例服用非典型抗精神病药物的住院患者进行回顾性分析,就便秘的情况和可能因素采用卡方检验对数据总结。结果:服用非典型抗精神病药物出现便秘的发生率为44.5%(236/530),不同非典型抗精神病药物导致便秘的发生率依次为氯氮平(63.6%)、齐拉西酮(59.1%)、喹硫平(55.2%)、氨磺必利(41.7%)、利培酮(41.1%)、奥氮平(40.8%)、阿立哌唑(6.3%),不同药物组间的差异有显著统计学意义(x^2=32.25,P<0.01)。非药物因素中,单一用药组与联用苯海索组的便秘发生率无统计学意义(P>0.05);女性出现便秘的发生率高于男性(x^2=5.70,P<0.05);不同年龄组的发生率有差异,患者年龄越小,出现便秘的机率越大(x^2=14.57,P<0.01);住院期间组间差异有统计学意义,住院时间越久,便秘的发病率越高(x^2=15.87,P<0.01)。结论:服用非典型抗精神病药物的患者便秘发生率高,便秘的发生率受药物类型、服药时间、年龄等多种因素的影响。
Objective： To explore incidence and risk factors of atypical antipsychotic drug-induced constipation. Methods：530 inpatients taking the atypical antipsychotic drugs were retrospectively analyzed. Chi-square analysis was used to analyze the constipation conditions and the potential factors. Results： The incidence rate of the atypical antipsychotic drug-induced constipation was44.5%（ 236/530）,including Clozapine 63.6%,Ziprasidone 59. 1%,Quetiapine 55. 2%,Amisulpride 41. 7%,Risperidone 41.1%,Olanzapine 40.8%,and Aripiprazole 6.3%,and the differences among different drugs were statistically significant（ x^2= 32.25,P〈0.01）. There was no significant difference in the incidence rate of constipation between monotherapy group and Benzhexol combination group（ P〉0.05）. The incidence rate of women was higher than that of men（ x^2= 5.70,P〈0.05）. There was the difference in the incidence rate of constipation among each age group,the younger the age was,the higher the incidence of constipation was（ x^2= 14.57,P〈0.05）. Further,there was the statistical difference in the incidence rate of constipation among difference hospital stay group,the longer the hospital stay was,the higher the incidence rate of constipation was. Conclusions： The incidence rate of the atypical antipsychotic drug-induced constipation is high,which is influenced by various factors,such as drug type,hospital stay,age,and so on.
出处
《中国民康医学》
2017年第13期3-4,7,共3页
Medical Journal of Chinese People’s Health
关键词
抗精神病药物
便秘
苯海索
Antipsychotic drug
Constipation
Benzhexol
