摘要
目的比较复方氯己定含漱液和康复新液治疗复发性阿弗他溃疡（RAU）的短期临床疗效。方法选取80例临床上确诊为复发性阿弗他溃疡的患者，并且随机分为两组，其中复方氯己定含漱液组40例，康复新液组40例，疗程均为1周，若疗程内痊愈即停药。患者于治疗后第7天复诊、治疗后第30天电话随访。评估两组患者临床疗效的差异。结果氯己定液组止痛起效时间[（6．24±1．09）min]短于康复新液组[（8．62±1．04）min]，差异有统计学意义（P〈0．01）；氯己定液组止痛维持时间[（29．47±3．45）min]长于康复新液组[（21．61±2．18）min]，差异均有统计学意义（P〈0．01）。氯己定液组用药后平均溃疡期（5．97±0．87）d，康复新液组（4．76±1．14）d，差异有统计学意义（P〈0．01）；两组在延长RAU间歇期方面差异无统计学意义（P〉0．05）。结论复方氯己定含漱液和康复新液治疗RAU均取得一定临床疗效，其中复方氯己定含漱液止痛起效快，维持时间长；康复新液在促进溃疡愈合方面更具有优势。短期使用氯己定液及康复新液尚不能延长RAU间歇期。
Objective To investigate the short-term efficacy of compound gargle solution chlorhexi- dine giuconatie and kangfuxin liquid in treatment of recurrent aphthous ulcer （RAU）. Methods Eighty patients clinically diagnosed with RAU were chosen and randomly divided into two groups. Test group 1 （40 cases） and Test group 2 （40 cases） were treated with compound gargle solution chlorhexidine giuconatie and kangfuxin liquid respectively until ulcer has been healed completely to evaluate the difference of two groups in clinical efficacy. Return visit and follow-up visit were conducted 7 days and 30 days after the initial treatment, respectively. Results The analgesic onset time of Test group 1 [ （6. 24 ±1.09 ） min] was shorter than that of Test group 2 [ （8.62 ±1.04）min ], with statistically significant difference （P 〈 0. 01 ）. The analgesic maintenance time of Test group 1 [ （29.47 ± 3.45 ）mini was longer than that of Test group 2 [ （21.61 ±2. 18） min], with statistically significant difference （ all P 〈 0. 01 ）. The duration of ulcer of Test groups 1 and 2 was （5.97±0. 87）days and （4. 76 ±1.14）days, with statistically significant difference （P 〈0. 01 ）. Conclusions Compound gargle solution chlorhexidine giuconatie and kangfuxin liquid both have a certain level of clinical efficacy for RAU, with the former featuring shorter analgesic onset time and longer duration and the latter advantageous in promoting RAU healing short-term usage of compound gargle solution chlorhexidine giuconatie and kangfuxin liquid cannot prolong RAU dormancy.
出处
《中国医师杂志》
CAS
2017年第9期1302-1304,1308,共4页
Journal of Chinese Physician
基金
国家自然科学基金项目（81570978,81400521）
江苏省临床医学科技专项（BL2014018）
