摘要
目的探讨两种不同胚胎装载技术对体外受精-胚胎移植(IVF-ET)和冻融胚胎移植(FET)临床妊娠率及胚胎种植率的影响。方法回顾性分析了543个新鲜胚胎移植周期及658个FET周期。根据移植时胚胎装载方法分为A组(含胚培养液体积>周围空气体积)和B组(含胚培养液体积<周围空气体积)。比较两种胚胎装载方法对妊娠结局的影响。结果新鲜周期中,B组的临床妊娠率(64.52%)显著高于A组(54.62%)(P<0.05),种植率组间虽无统计学差异(P>0.05),但B组明显高于A组。FET周期中卵裂胚移植B组的临床妊娠率(49.43%)明显高于A组(38.24%),但没有统计学差异(P>0.05),B组(34.62%)的种植率显著高于A组(23.61%)(P<0.05)。囊胚移植两组的妊娠率和种植率均没有统计学差异(P>0.05),但B组比A组有增高的趋势。结论胚胎移植时含胚培养液体积<周围空气体积会显著提高IVF-ET和FET的临床妊娠率和种植率。
Objective To evaluate the impact of two different embryo loading techniques on pregancy rates and implantation rate m in vitro fertilization and embryo transfer （IVF-ET） cycles and frozen-thawed embryo transfer （FET） cycles. Methods We retrospectively analyzed 543 fresh ET cycles and 658 FET cycles. The patients were placed m group A and group B, group A： the volume of medium containing embryos〉air bubble surrounding it; group B： the volume of medium containing embryos〈air bubble surrounding it. The pregnancy outcome was compared between the two groups. Results In fresh ET cycles, the pregnancy rate m group B （64.52%） was significantly higher than that m group A （54.62%） （P〈0.05）. There was no significant difference of implantation rate in groups A and B, but it was higher m group B than in group A obviously. In FET cycles, the cleavage embryo pregnancy m group B was higher than that m group A obviously, but there was no significant difference （P〉0.05）. The implantation rate was higher in group B （39.51%） than in group A （26.81%）, the difference was significant （P〈0.05）. There were no significant differences in beth pregnancy rate and implantation rate of blastocyst, but it was higher in group B than in group A. Conclusion The volume of medium containing embryos 〈 air bubble surrounding it can significantly improve the pregnancy rate and implantation rate m fresh ET cycles and FET cycles.
出处
《中华生殖与避孕杂志》
CAS
CSCD
北大核心
2017年第8期643-647,共5页
Chinese Journal of Reproduction and Contraception
