摘要
目的:研究五苓散辅助罗格列酮治疗糖尿病肾病的临床疗效。方法:选取我院2012年2月至2014年8月68例糖尿病肾病患者为研究对象,将患者随机分为观察组和对照组,每组34例,观察组采用五苓散辅助罗格列酮,对照组采用单纯西药罗格列酮,比较两组的临床疗效,血糖、血脂指标,尿蛋白、肾功能指标以及不良反应。结果:观察组的治疗总有效率为94.1%,显著高于对照组的76.5%,观察组治疗后的空腹血糖、餐后2小时血糖、三酰甘油酯、24h尿微量白蛋白排泄率、血肌酐、血尿素氮分别为(5.48±2.66)mmol/L、(8.16±2.37)mmol/L、(2.04±0.85)mmol/L、(39.52±11.16)μg/min、(77.26±12.31)μmol/L、(7.16±2.57)mmol/L,显著低于对照组的(7.35±1.64)mmol/L、(10.42±3.41)mmol/L、(2.86±1.12)mmol/L、(45.35±11.52)μg/min、(86.48±12.09)μmol/L、(8.72±2.61)mmol/L。观察组的不良反应率为17.6%略高于对照组的14.7%,但差异不显著。结论:五苓散可辅助治疗糖尿病肾病,控制患者的血糖、血脂水平,改善患者肾功能。
Objective： To analyse the clinical efficacy of Wuling powder combined with rosiglitazone on diabetic nephropathy. Methods： 68 patients with diabetic nephropathy from February 2012 to August 2014 were grouped into the observation and the control group,each with 34 cases.Patients in the observation group were treated with Wuling powder combined with rosiglitazone,while those in the control group were treated with rosiglitazone. Clinical efficacy,blood sugar,blood lipid,urine protein,renal function and adverse reaction in two groups were compared. Results： Total effective rate in the observation group was 94. 12%,higher than that in the control group with 76. 47%（ P〈0. 05）.Levels of FPG,2h PBG,TG,LDL-C,UAER,SCr,BUN in the observation group were（ 5. 48 ± 2. 66） mmol/L,（ 8. 16 ± 2. 37） mmol/L,（ 2. 04± 0. 35） mmol/L,（ 2. 25 ± 0. 42） mmol/L,（ 39. 52 ± 3. 16） μg/min,（ 77. 2 ± 5. 3） μmol/L and（ 6. 16 ± 1. 57） mmol/L respectively,all lower than those in the control group（ 7. 35 ± 1. 64） mmol/L,（ 10. 42 ± 2. 41） mmol/L,（ 2. 86 ± 0. 42） mmol/L,（ 2. 84 ± 0. 54） mmol/L,（ 45. 35 ±4. 52） μg/min,（ 86. 4 ± 6. 0） μmol/L and（ 8. 72 ± 1. 61） mmol/L（ P〈0. 05）,then HDL-C level in the observation group was（ 2. 11 ± 0. 13）mmol/L,higher than that in the control group（ 1. 67 ± 0. 11） mmol/L（ P〈0. 05）. Adverse reaction in the observation group was 17. 65%,slightly higher than that in the control group with 14. 71%,but the difference was not statistically significant（ P〈0. 05）. Conclusion： Wuling powder can assist in the treatment of diabetic nephropathy,control the blood sugar and blood lipid level and improve renal function.
出处
《中药药理与临床》
CSCD
北大核心
2017年第4期176-178,共3页
Pharmacology and Clinics of Chinese Materia Medica
关键词
五苓散
罗格列酮
糖尿病肾病
Wuling Powder（五苓散）
rosiglitazone
diabetic nephropathy
