摘要
种子类中药逢子必炒的炮制理论具有丰富的科学内涵,但在种子类中药炒制机理研究中,其炒制过程的内在变化过程和变化规律尚不清楚,药效物质不明确,且缺少特征性质量标志物,难以有效控制质量。揭示种子类中药逢子必炒共性规律,对于建立中药饮片特征性质量标准具有指导意义。基于逢子必炒炮制理论的研究,提出采用谱效相关分析的研究方法,研究炒制过程化学成分及药效作用变化,阐明其药效物质基础,揭示炒制过程共性变化规律;同时,结合体内过程研究,阐明炒制过程对药效物质的影响,进而明确中药的体内药效物质基础;在此基础上,采用一测多评技术和液质联用技术等方法,研究建立中药饮片特征性质量标准,指导中药饮片规范化炮制和临床合理使用。
The processing theory of seed drugs be stir-heated before using for the seed medicine has a rich scientific conno- tation. However, the internal chemical changes and changing laws are not clear, the effective substances are not definite, and characteristic quality standards are in need, so it is difficult to control the quality of the seed drugs effectively. When processing the Chinese herbal medicines, the same technical methods may cause some common reactions frequently. Revealing the com- mon mechanism of seed drugs be stir-heated before using in this further study has guiding meaning to establish characteristic quality standards. On the basic of the theory of seed drugs be stir-heated, this study will use the spectrum-activity relationship method to study the changes of the chemical composition and pharmacological effect, clarify the effective basis, and reveal com- mon mechanism during the stir-flying process. Meanwhile, this paper will use pharmacokinetics method to clarify the effective substances in vivo of Chinese medicine. On this basis, multi-components by one marker, LC-MS and other methods will be employed to establish characteristic standards for these seed drugs, and then to guide the standardized production and clinical use of seed drugs.
出处
《南京中医药大学学报》
CAS
CSCD
北大核心
2017年第5期443-447,共5页
Journal of Nanjing University of Traditional Chinese Medicine
基金
国家自然科学基金(81573603)
国家自然科学基金青年基金(81603297)
国家中医药管理局公益性行业专项(201507002-2)
江苏省普通高校研究生科研创新计划(KYZZ16_0413)
江苏省临床药学科研项目(2015YX005)
关键词
逢子必炒
炮制机理
质量标准
中药
seed drugs be stir-heated
processing mechanism
quality standard
Chinese medicine
