摘要
在细乳液反应体系中,以阳离子型乳化剂稳定的纳米油滴为模板,通过正硅酸乙酯(TEOS)的界面水解-缩合反应制备Si O_2纳米胶囊,并将其用于装载姜黄素。采用动态光散射和透射电镜研究了Si O_2纳米胶囊的尺寸和形态;采用红外光谱和热失重测试研究了Si O_2纳米胶囊装载姜黄素的能力;采用紫外-可见分光光度计研究了装载姜黄素的Si O_2纳米粒子的姜黄素缓释动力学。结果表明:细乳液法能高效地制备Si O_2纳米胶囊,其尺寸和壳壁稳定性能通过阳离子乳化剂和TEOS的用量调控;Si O_2纳米胶囊能高效地装载姜黄素,且对其有一定的缓释效果。
Silica nanocapsules were successfully prepared through an interfacial hydrolysis-condensation reaction in miniemulsions by using cationic surfactant stabilized oil droplets as soft templates. The particle size and morphology of silica nanocapsules were characterized by transmission electron microscopy and dynamic light scattering. The results pointed out that the particle size and morphology could be conveniently tuned by the amount of cetyltrimethylammonium bromide and the weight content of TEOS in oil phase. The nitrogen sorption analysis showed that the silica shell had a mesoporous structure. The Fourier transform infrared spectra and thermogravimetric analyses indicated that curcumin was successfully loaded by silica nanocapsules. The loaded curcumin could be released from silica nanoparticles,displaying a sustained release behavior.
作者
崔勤敏
姚莹
施琦渊
杜文婷
CUI Qin-min YAO Ying SHI Qi-yuan DU Wen-ting(School of Pharmacy, Hangzhou Medical College, Hangzhou, Zhejiang 310053, China)
出处
《浙江化工》
CAS
2017年第9期45-50,共6页
Zhejiang Chemical Industry
基金
浙江医学高等专科学校科技计划项目(2008XZA02)
